Stability of Th1 and Th2 populations

Victor L. Perez, James A. Lederer, Andrew H. Lichtman, Abul K. Abbas

Research output: Contribution to journalArticle

155 Scopus citations

Abstract

Using an in vitro model for the development of IFN-γ-producing (T(h)1) and IL-4-producing (T(h)2) cells from CD4+ T lymphocytes expressing a transgenic TCR, we show that IL-12 and IL-4 are the most potent stimuli for the differentiation of naive T cells to effector populations. When combinations of cytokines are present during T cell priming, the effect of IL-4 is dominant. Furthermore, differentiated T(h)1 cells can be converted into IL-4 producers by exposure to IL-4, but the T(h)2 phenotype is not reversible. The stability of T(h)2 populations may limit the ability to regulate T(h)2-dominant responses in pathologic situations.

Original languageEnglish (US)
Pages (from-to)869-875
Number of pages7
JournalInternational Immunology
Volume7
Issue number5
DOIs
StatePublished - May 1 1995

Keywords

  • Cytokine
  • Helper
  • T cell

ASJC Scopus subject areas

  • Immunology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Transplantation

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