Stability and bifurcation analysis of a two-patch SIS model on nosocomial infections

Xiaomei Feng, Lili Liu, Sanyi Tang, Xi Huo

Research output: Contribution to journalArticle


We use a two-patch model to address the spread of antibiotic-resistant bacteria (ARB) within and between hospitals. Specifically, we consider patients being referred and transferred from a small community hospital with inappropriate antibiotic use to a large teaching hospital with good antibiotic treatment. Our analyses show that screening and decolonizing patients transferred between hospitals and avoiding misuse of antibiotics are both crucial factors to contain nosocomial infections.

Original languageEnglish (US)
Article number106097
JournalApplied Mathematics Letters
StatePublished - Apr 2020



  • Antibiotic resistance
  • Backward bifurcation
  • Global stability
  • Patch model

ASJC Scopus subject areas

  • Applied Mathematics

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