Src-mediated regulation of E-cadherin and EMT in pancreatic cancer

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The Src family of non receptor tyrosine kinases are integrators of divergent signal transduction pathways which regulate numerous cellular processes, including tumorigenicity and angiogenesis. In pancreatic adenocarcinoma, c-Src (Src) is frequently activated and results in increased tumor progression, invasion and metastasis. Dysfunction of the E-cadherin-mediated cell adhesion system plays an important role in tumor progression to invasive, metastatic carcinoma. Src has been shown to play a role in E-cadherin regulation and epithelial to mesenchymal transition (EMT). Increased Src activity promotes EMT while Src inhibition suppresses this process. Recent studies have focused on Src dependent regulation of E-cadherin and other tumor progression-related events such as EMT with the development of metastasis. Src has also been shown to be involved in chemoresistance of PDAC cells by promoting EMT. Although the molecular events associated with Src-dependent regulation of E-cadherin are becoming better defined, the cellular processes that trigger the onset of EMT remain unclear. Here we highlight recent work that advances our understanding of Src signaling as it relates to E-cadherin associated regulation and EMT in PDAC.

Original languageEnglish (US)
Pages (from-to)2059-2069
Number of pages11
JournalFrontiers in Bioscience
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Fingerprint

Epithelial-Mesenchymal Transition
Cadherins
Pancreatic Neoplasms
Tumors
Signal transduction
Neoplasm Metastasis
Cell adhesion
Receptor Protein-Tyrosine Kinases
Neoplasms
Cell Adhesion
Signal Transduction
Adenocarcinoma
Carcinoma

Keywords

  • E-cadherin
  • EMT
  • Metastasis
  • Pancreatic cancer
  • Review
  • Src
  • STAT3

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Src-mediated regulation of E-cadherin and EMT in pancreatic cancer. / Nagathihalli, Nagaraj; Merchant, Nipun.

In: Frontiers in Bioscience, Vol. 17, No. 6, 01.06.2012, p. 2059-2069.

Research output: Contribution to journalArticle

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