Squamous cell carcinoma arising in dedifferentiated chondrosarcoma proved by isocitrate dehydrogenase mutation analysis

Yaxia Zhang, Ana Paz Mejia, H. Thomas Temple, Jonathan Trent, Andrew Rosenberg

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Dedifferentiated chondrosarcoma is a primary bone tumor characterized by the presence of both low-grade cartilaginous and high-grade malignant noncartilaginous components. The high-grade noncartilaginous component is typically a pleomorphic fibroblastic spindle cell sarcoma. Dedifferentiation into a malignant epithelial component is extremely rare. In this report, we present a 74-year-old woman who developed a metastatic squamous cell carcinoma in the right inguinal area 1 year after wide resection of her right proximal femur for a dedifferentiated chondrosarcoma. The dedifferentiated component was composed of poorly differentiated epithelioid cells with foci of squamous cell carcinoma. Mutational analysis was performed, and the isocitrate dehydrogenase 1 R132C mutation was detected in the low-grade chondrosarcoma, dedifferentiated chondrosarcoma as well as the metastatic squamous cell carcinoma. And this mutation was not detected in patient's normal tissue. Our study supports the theory that both the chondrosarcoma cells and dedifferentiated epithelioid tumor cells arose from the same clonal origin.

Original languageEnglish
Pages (from-to)1541-1545
Number of pages5
JournalHuman Pathology
Volume45
Issue number7
DOIs
StatePublished - Jan 1 2014

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Isocitrate Dehydrogenase
Chondrosarcoma
Squamous Cell Carcinoma
Mutation
Epithelioid Cells
Groin
Sarcoma
Femur
Neoplasms
Bone and Bones

Keywords

  • Chondrosarcoma
  • Dedifferentiation
  • IDH
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Squamous cell carcinoma arising in dedifferentiated chondrosarcoma proved by isocitrate dehydrogenase mutation analysis. / Zhang, Yaxia; Paz Mejia, Ana; Thomas Temple, H.; Trent, Jonathan; Rosenberg, Andrew.

In: Human Pathology, Vol. 45, No. 7, 01.01.2014, p. 1541-1545.

Research output: Contribution to journalArticle

Zhang, Yaxia ; Paz Mejia, Ana ; Thomas Temple, H. ; Trent, Jonathan ; Rosenberg, Andrew. / Squamous cell carcinoma arising in dedifferentiated chondrosarcoma proved by isocitrate dehydrogenase mutation analysis. In: Human Pathology. 2014 ; Vol. 45, No. 7. pp. 1541-1545.
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