TY - JOUR
T1 - Spontaneous remission of acute myeloid leukemia with NF1 alteration
AU - Bradley, Terrence
AU - Zuquello, Radames Adamo
AU - Aguirre, Luis E.
AU - Mackrides, Nicholas
AU - Chapman, Jennifer
AU - Cimmino, Luisa
AU - Thomassen, Amber
AU - Watts, Justin
N1 - Publisher Copyright:
© 2020
PY - 2020
Y1 - 2020
N2 - Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. We review the literature and assess the trends associated with SR, and report a new case of a 58-year-old man with a morphologic diagnosis of AML associated with a severe gastrointestinal (GI) tract infection. The patient had an NF1 variant that was previously unreported in AML as the only clonal abnormality. After treatment of the infection, the increased blast population subsided with no leukemia-directed therapy, and the patient has remained in a continuous, spontaneous complete remission for > 2 years.
AB - Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. We review the literature and assess the trends associated with SR, and report a new case of a 58-year-old man with a morphologic diagnosis of AML associated with a severe gastrointestinal (GI) tract infection. The patient had an NF1 variant that was previously unreported in AML as the only clonal abnormality. After treatment of the infection, the increased blast population subsided with no leukemia-directed therapy, and the patient has remained in a continuous, spontaneous complete remission for > 2 years.
KW - Acute myeloid leukemia
KW - Clonal hematopoiesis
KW - Leukemoid reaction
KW - NF1 alteration
KW - Spontaneous remission
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U2 - 10.1016/j.lrr.2020.100204
DO - 10.1016/j.lrr.2020.100204
M3 - Article
AN - SCOPUS:85085289643
VL - 13
JO - Leukemia Research Reports
JF - Leukemia Research Reports
SN - 2213-0489
M1 - 100204
ER -