Spontaneous remission of acute myeloid leukemia with NF1 alteration

Terrence Bradley; Radames Adamo Zuquello; Luis E. Aguirre; Nicholas Mackrides; Jennifer Chapman; Luisa Cimmino; Amber Thomassen; Justin Watts

doi:10.1016/j.lrr.2020.100204

Spontaneous remission of acute myeloid leukemia with NF1 alteration

Terrence Bradley, Radames Adamo Zuquello, Luis E. Aguirre, Nicholas Mackrides, Jennifer Chapman, Luisa Cimmino, Amber Thomassen, Justin Watts

Research output: Contribution to journal › Article › peer-review

Abstract

Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. We review the literature and assess the trends associated with SR, and report a new case of a 58-year-old man with a morphologic diagnosis of AML associated with a severe gastrointestinal (GI) tract infection. The patient had an NF1 variant that was previously unreported in AML as the only clonal abnormality. After treatment of the infection, the increased blast population subsided with no leukemia-directed therapy, and the patient has remained in a continuous, spontaneous complete remission for > 2 years.

Original language	English (US)
Article number	100204
Journal	Leukemia Research Reports
Volume	13
DOIs	https://doi.org/10.1016/j.lrr.2020.100204
State	Published - 2020

Keywords

Acute myeloid leukemia
Clonal hematopoiesis
Leukemoid reaction
NF1 alteration
Spontaneous remission

ASJC Scopus subject areas

Hematology
Oncology

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title = "Spontaneous remission of acute myeloid leukemia with NF1 alteration",

abstract = "Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. We review the literature and assess the trends associated with SR, and report a new case of a 58-year-old man with a morphologic diagnosis of AML associated with a severe gastrointestinal (GI) tract infection. The patient had an NF1 variant that was previously unreported in AML as the only clonal abnormality. After treatment of the infection, the increased blast population subsided with no leukemia-directed therapy, and the patient has remained in a continuous, spontaneous complete remission for > 2 years.",

keywords = "Acute myeloid leukemia, Clonal hematopoiesis, Leukemoid reaction, NF1 alteration, Spontaneous remission",

author = "Terrence Bradley and Zuquello, {Radames Adamo} and Aguirre, {Luis E.} and Nicholas Mackrides and Jennifer Chapman and Luisa Cimmino and Amber Thomassen and Justin Watts",

year = "2020",

doi = "10.1016/j.lrr.2020.100204",

language = "English (US)",

volume = "13",

journal = "Leukemia Research Reports",

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T1 - Spontaneous remission of acute myeloid leukemia with NF1 alteration

AU - Bradley, Terrence

AU - Zuquello, Radames Adamo

AU - Aguirre, Luis E.

AU - Mackrides, Nicholas

AU - Chapman, Jennifer

AU - Cimmino, Luisa

AU - Thomassen, Amber

AU - Watts, Justin

PY - 2020

Y1 - 2020

N2 - Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. We review the literature and assess the trends associated with SR, and report a new case of a 58-year-old man with a morphologic diagnosis of AML associated with a severe gastrointestinal (GI) tract infection. The patient had an NF1 variant that was previously unreported in AML as the only clonal abnormality. After treatment of the infection, the increased blast population subsided with no leukemia-directed therapy, and the patient has remained in a continuous, spontaneous complete remission for > 2 years.

AB - Acute myeloid leukemia (AML) is defined by the presence of ≥ 20% myeloblasts in the blood or bone marrow. Spontaneous remission (SR) of AML is a rare event, with few cases described in the literature. SR is generally associated with recovery from an infectious or immunologic process, and more recently possibly with clonal hematopoiesis. We review the literature and assess the trends associated with SR, and report a new case of a 58-year-old man with a morphologic diagnosis of AML associated with a severe gastrointestinal (GI) tract infection. The patient had an NF1 variant that was previously unreported in AML as the only clonal abnormality. After treatment of the infection, the increased blast population subsided with no leukemia-directed therapy, and the patient has remained in a continuous, spontaneous complete remission for > 2 years.

KW - Acute myeloid leukemia

KW - Clonal hematopoiesis

KW - Leukemoid reaction

KW - NF1 alteration

KW - Spontaneous remission

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