Spontaneous remission of acute leukemia after the termination of pregnancy

J. Antunez De Mayolo, Yeon Ahn, J. D. Temple, W. J. Harrington

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A 28-year-old woman in the third trimester of her pregnancy was found to have acute myelocytic leukemia. The baby was delivered by Cesarean section and her leukemia underwent spontaneous remission. However, 3 months later, she presented with massive painful leukemic infiltration of the breasts as initial manifestation of relapse, followed by systemic symptoms of leukemia. In vitro culture of the leukemic cells demonstrated characteristics of macrophage cell line. This case illustrates a unique sequence of events: spontaneous remission after the termination of pregnancy, which has profound hormonal alterations, and relapse in a very hormone-sensitive organ, the breast, a few months later when the hormonal milieu was resumed. This suggests hormonal dependence of her leukemic cells and potential for hormonal manipulation in a certain subset of human leukemia.

Original languageEnglish
Pages (from-to)1621-1623
Number of pages3
JournalCancer
Volume63
Issue number8
StatePublished - Jan 1 1989

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Spontaneous Remission
Leukemia
Pregnancy
Breast
Leukemic Infiltration
Recurrence
Third Pregnancy Trimester
Acute Myeloid Leukemia
Cesarean Section
Cell Culture Techniques
Macrophages
Hormones
Cell Line

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Antunez De Mayolo, J., Ahn, Y., Temple, J. D., & Harrington, W. J. (1989). Spontaneous remission of acute leukemia after the termination of pregnancy. Cancer, 63(8), 1621-1623.

Spontaneous remission of acute leukemia after the termination of pregnancy. / Antunez De Mayolo, J.; Ahn, Yeon; Temple, J. D.; Harrington, W. J.

In: Cancer, Vol. 63, No. 8, 01.01.1989, p. 1621-1623.

Research output: Contribution to journalArticle

Antunez De Mayolo, J, Ahn, Y, Temple, JD & Harrington, WJ 1989, 'Spontaneous remission of acute leukemia after the termination of pregnancy', Cancer, vol. 63, no. 8, pp. 1621-1623.
Antunez De Mayolo J, Ahn Y, Temple JD, Harrington WJ. Spontaneous remission of acute leukemia after the termination of pregnancy. Cancer. 1989 Jan 1;63(8):1621-1623.
Antunez De Mayolo, J. ; Ahn, Yeon ; Temple, J. D. ; Harrington, W. J. / Spontaneous remission of acute leukemia after the termination of pregnancy. In: Cancer. 1989 ; Vol. 63, No. 8. pp. 1621-1623.
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