Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

Vishal Bhagat, Julie A. Foont, Eugene R. Schiff, Arie Regev

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HCV-HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti-HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long-term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV-HCV-coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear.

Original languageEnglish (US)
Pages (from-to)92-95
Number of pages4
JournalLiver Transplantation
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

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