Abstract
Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HCV-HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti-HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long-term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV-HCV-coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear.
| Original language | English |
|---|---|
| Pages (from-to) | 92-95 |
| Number of pages | 4 |
| Journal | Liver Transplantation |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2008 |
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ASJC Scopus subject areas
- Surgery
- Transplantation
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Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus. / Bhagat, Vishal; Foont, Julie A.; Schiff, Eugene R; Regev, Arie.
In: Liver Transplantation, Vol. 14, No. 1, 01.01.2008, p. 92-95.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus
AU - Bhagat, Vishal
AU - Foont, Julie A.
AU - Schiff, Eugene R
AU - Regev, Arie
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HCV-HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti-HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long-term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV-HCV-coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear.
AB - Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HCV-HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti-HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long-term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV-HCV-coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear.
UR - http://www.scopus.com/inward/record.url?scp=38649123388&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38649123388&partnerID=8YFLogxK
U2 - 10.1002/lt.21351
DO - 10.1002/lt.21351
M3 - Article
C2 - 18161776
AN - SCOPUS:38649123388
VL - 14
SP - 92
EP - 95
JO - Liver Transplantation
JF - Liver Transplantation
SN - 1527-6465
IS - 1
ER -