Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus

Vishal Bhagat, Julie A. Foont, Eugene R Schiff, Arie Regev

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Spontaneous resolution of chronic hepatitis C virus (HCV) infection is exceedingly rare and poorly understood. As HCV and human immunodeficiency virus (HIV) have shared routes of transmission, HCV coinfection is estimated to affect 15%-30% of the HIV-positive population. We report 2 patients with HCV-HIV coinfection who underwent orthotopic liver transplantation at our center and had spontaneous clearance of their chronic HCV infection after transplantation without any anti-HCV treatment. Both patients showed no evidence of HCV recurrence for more than 3 years despite long-term immunosuppressant therapy. Spontaneous clearance of chronic HCV infection can occur in HIV-HCV-coinfected patients after liver transplantation. The mechanism of this phenomenon remains unclear.

Original languageEnglish
Pages (from-to)92-95
Number of pages4
JournalLiver Transplantation
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2008

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Hepacivirus
Liver Transplantation
HIV
Chronic Hepatitis C
Virus Diseases
Coinfection
Immunosuppressive Agents
Transplantation
Recurrence
Therapeutics
Population

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Spontaneous clearance of hepatitis C virus after liver transplantation in two patients coinfected with hepatitis C virus and human immunodeficiency virus. / Bhagat, Vishal; Foont, Julie A.; Schiff, Eugene R; Regev, Arie.

In: Liver Transplantation, Vol. 14, No. 1, 01.01.2008, p. 92-95.

Research output: Contribution to journalArticle

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