Splenic marginal zone lymphomas are characterized by loss of interstitial regions of chromosome 7q, 7q31.32 and 7q36.2 that include the protection of telomere 1 (POT1) and sonic hedgehog (SHH) genes

Francisco Vega, Jeong Hee Cho, Patrick A. Lennon, Madan G. Luthra, Jaime Bailey, Megan Breeden, Dan Jones, L. Jeffrey Medeiros, Rajyalakshmi Luthra

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

To further characterize the genotypic features of splenic (S) and nodal (N) marginal zone lymphomas (MZL) we compared eight SMZL and five NMZL by array-based comparative genomic hybridization (aCGH). Arbitrarily, aberrations were divided into major imbalances, defined as gains or losses involving five or more contiguous genetic loci, and minor imbalances, defined as those involving four or fewer loci. SMZL, but not NMZL, demonstrated major imbalances. These included deletions involving various lengths of 7q (three cases), and 14q23q24 (one case) and gains of 9p13p21 (one case), 13q21q33 (one case) and 16p13.1 (one case). Common minor imbalances in SMZL were: loss of sonic hedgehog gene (SHH) at 7q36.2 (four cases), loss of protection of telomere 1 gene (POT1) at 7q31.32 (three cases), and gain of glioma associated oncogene 1 (GLI1) at 12q13.2 (three cases). Common minor alterations in NMZL were: loss of the fas-associated via death domain gene (FADD) at 11q13.2 (three cases) and gain of GLI1 (five cases). In conclusion, SMZL, but not NMZL, demonstrates large genomic imbalances and frequent loss of the 7q31.32 and 7q36.2 regions involving POT1 and SHH, respectively. In NMZL, loss of FADD and gain of GLI1 are frequent events.

Original languageEnglish
Pages (from-to)216-226
Number of pages11
JournalBritish Journal of Haematology
Volume142
Issue number2
DOIs
StatePublished - Jul 1 2008
Externally publishedYes

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Telomere
Lymphoma
Chromosomes
Genes
Genetic Loci
Comparative Genomic Hybridization
Oncogenes
Glioma
Death Domain

Keywords

  • aCGH
  • Nodal marginal zone lymphoma
  • POT1 gene
  • SHH/GLI1 pathway
  • Splenic marginal zone lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

Splenic marginal zone lymphomas are characterized by loss of interstitial regions of chromosome 7q, 7q31.32 and 7q36.2 that include the protection of telomere 1 (POT1) and sonic hedgehog (SHH) genes. / Vega, Francisco; Cho, Jeong Hee; Lennon, Patrick A.; Luthra, Madan G.; Bailey, Jaime; Breeden, Megan; Jones, Dan; Medeiros, L. Jeffrey; Luthra, Rajyalakshmi.

In: British Journal of Haematology, Vol. 142, No. 2, 01.07.2008, p. 216-226.

Research output: Contribution to journalArticle

Vega, Francisco ; Cho, Jeong Hee ; Lennon, Patrick A. ; Luthra, Madan G. ; Bailey, Jaime ; Breeden, Megan ; Jones, Dan ; Medeiros, L. Jeffrey ; Luthra, Rajyalakshmi. / Splenic marginal zone lymphomas are characterized by loss of interstitial regions of chromosome 7q, 7q31.32 and 7q36.2 that include the protection of telomere 1 (POT1) and sonic hedgehog (SHH) genes. In: British Journal of Haematology. 2008 ; Vol. 142, No. 2. pp. 216-226.
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abstract = "To further characterize the genotypic features of splenic (S) and nodal (N) marginal zone lymphomas (MZL) we compared eight SMZL and five NMZL by array-based comparative genomic hybridization (aCGH). Arbitrarily, aberrations were divided into major imbalances, defined as gains or losses involving five or more contiguous genetic loci, and minor imbalances, defined as those involving four or fewer loci. SMZL, but not NMZL, demonstrated major imbalances. These included deletions involving various lengths of 7q (three cases), and 14q23q24 (one case) and gains of 9p13p21 (one case), 13q21q33 (one case) and 16p13.1 (one case). Common minor imbalances in SMZL were: loss of sonic hedgehog gene (SHH) at 7q36.2 (four cases), loss of protection of telomere 1 gene (POT1) at 7q31.32 (three cases), and gain of glioma associated oncogene 1 (GLI1) at 12q13.2 (three cases). Common minor alterations in NMZL were: loss of the fas-associated via death domain gene (FADD) at 11q13.2 (three cases) and gain of GLI1 (five cases). In conclusion, SMZL, but not NMZL, demonstrates large genomic imbalances and frequent loss of the 7q31.32 and 7q36.2 regions involving POT1 and SHH, respectively. In NMZL, loss of FADD and gain of GLI1 are frequent events.",
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AU - Vega, Francisco

AU - Cho, Jeong Hee

AU - Lennon, Patrick A.

AU - Luthra, Madan G.

AU - Bailey, Jaime

AU - Breeden, Megan

AU - Jones, Dan

AU - Medeiros, L. Jeffrey

AU - Luthra, Rajyalakshmi

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