Abstract
An evaluation of various parameters of the immune system was undertaken in Balb/c mice transplanted with a syngeneic mammary adenocarcinoma. Increasing tumor burdens resulted in a depression of some cell mediated immune functions. In contrast, an augmentation of humoral responses was observed in tumor-bearing mice. A defect in the immunoregulatory mechanism did not appear to be responsible for the elevated humoral response as revealed in suppressor cell experiments. However, flow cytometric analysis of T and B lymphocyte levels in the spleens of mice with mammary tumors indicated that the numbers of Thy 1.2 positive cells were greatly diminished while there was only a slight increase in the proportion of cells bearing surface immunoglobulin. These splenic alterations accompanying tumor growth might be responsible for the altered immune responses observed in tumor-bearing animals.
Original language | English (US) |
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Pages (from-to) | 63-69 |
Number of pages | 7 |
Journal | Anticancer research |
Volume | 1 |
Issue number | 2 |
State | Published - Dec 1 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research