Splenic alterations during mammary tumorigenesis: Diverse effects on different immune parameters

R. D. Paul, A. Ghaffar, M. M. Sigel, V. Charyulu, D. M. Lopez

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


An evaluation of various parameters of the immune system was undertaken in Balb/c mice transplanted with a syngeneic mammary adenocarcinoma. Increasing tumor burdens resulted in a depression of some cell mediated immune functions. In contrast, an augmentation of humoral responses was observed in tumor-bearing mice. A defect in the immunoregulatory mechanism did not appear to be responsible for the elevated humoral response as revealed in suppressor cell experiments. However, flow cytometric analysis of T and B lymphocyte levels in the spleens of mice with mammary tumors indicated that the numbers of Thy 1.2 positive cells were greatly diminished while there was only a slight increase in the proportion of cells bearing surface immunoglobulin. These splenic alterations accompanying tumor growth might be responsible for the altered immune responses observed in tumor-bearing animals.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalAnticancer research
Issue number2
StatePublished - Dec 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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