Abstract
An evaluation of various parameters of the immune system was undertaken in Balb/c mice transplanted with a syngeneic mammary adenocarcinoma. Increasing tumor burdens resulted in a depression of some cell mediated immune functions. In contrast, an augmentation of humoral responses was observed in tumor-bearing mice. A defect in the immunoregulatory mechanism did not appear to be responsible for the elevated humoral response as revealed in suppressor cell experiments. However, flow cytometric analysis of T and B lymphocyte levels in the spleens of mice with mammary tumors indicated that the numbers of Thy 1.2 positive cells were greatly diminished while there was only a slight increase in the proportion of cells bearing surface immunoglobulin. These splenic alterations accompanying tumor growth might be responsible for the altered immune responses observed in tumor-bearing animals.
| Original language | English |
|---|---|
| Pages (from-to) | 63-69 |
| Number of pages | 7 |
| Journal | Anticancer Research |
| Volume | 1 |
| Issue number | 2 |
| State | Published - Dec 1 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Splenic alterations during mammary tumorigenesis : Diverse effects on different immune parameters. / Paul, R. D.; Ghaffar, A.; Sigel, M. M.; Charyulu, V.; Lopez, Diana M.
In: Anticancer Research, Vol. 1, No. 2, 01.12.1981, p. 63-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Splenic alterations during mammary tumorigenesis
T2 - Diverse effects on different immune parameters
AU - Paul, R. D.
AU - Ghaffar, A.
AU - Sigel, M. M.
AU - Charyulu, V.
AU - Lopez, Diana M
PY - 1981/12/1
Y1 - 1981/12/1
N2 - An evaluation of various parameters of the immune system was undertaken in Balb/c mice transplanted with a syngeneic mammary adenocarcinoma. Increasing tumor burdens resulted in a depression of some cell mediated immune functions. In contrast, an augmentation of humoral responses was observed in tumor-bearing mice. A defect in the immunoregulatory mechanism did not appear to be responsible for the elevated humoral response as revealed in suppressor cell experiments. However, flow cytometric analysis of T and B lymphocyte levels in the spleens of mice with mammary tumors indicated that the numbers of Thy 1.2 positive cells were greatly diminished while there was only a slight increase in the proportion of cells bearing surface immunoglobulin. These splenic alterations accompanying tumor growth might be responsible for the altered immune responses observed in tumor-bearing animals.
AB - An evaluation of various parameters of the immune system was undertaken in Balb/c mice transplanted with a syngeneic mammary adenocarcinoma. Increasing tumor burdens resulted in a depression of some cell mediated immune functions. In contrast, an augmentation of humoral responses was observed in tumor-bearing mice. A defect in the immunoregulatory mechanism did not appear to be responsible for the elevated humoral response as revealed in suppressor cell experiments. However, flow cytometric analysis of T and B lymphocyte levels in the spleens of mice with mammary tumors indicated that the numbers of Thy 1.2 positive cells were greatly diminished while there was only a slight increase in the proportion of cells bearing surface immunoglobulin. These splenic alterations accompanying tumor growth might be responsible for the altered immune responses observed in tumor-bearing animals.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019858608&partnerID=8YFLogxK
M3 - Article
VL - 1
SP - 63
EP - 69
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 2
ER -