Splenic alterations during mammary tumorigenesis

Diverse effects on different immune parameters

R. D. Paul, A. Ghaffar, M. M. Sigel, V. Charyulu, Diana M Lopez

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

An evaluation of various parameters of the immune system was undertaken in Balb/c mice transplanted with a syngeneic mammary adenocarcinoma. Increasing tumor burdens resulted in a depression of some cell mediated immune functions. In contrast, an augmentation of humoral responses was observed in tumor-bearing mice. A defect in the immunoregulatory mechanism did not appear to be responsible for the elevated humoral response as revealed in suppressor cell experiments. However, flow cytometric analysis of T and B lymphocyte levels in the spleens of mice with mammary tumors indicated that the numbers of Thy 1.2 positive cells were greatly diminished while there was only a slight increase in the proportion of cells bearing surface immunoglobulin. These splenic alterations accompanying tumor growth might be responsible for the altered immune responses observed in tumor-bearing animals.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalAnticancer Research
Volume1
Issue number2
StatePublished - Dec 1 1981
Externally publishedYes

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Carcinogenesis
Breast
Neoplasms
B-Cell Antigen Receptors
Tumor Burden
Immune System
Adenocarcinoma
B-Lymphocytes
Spleen
Breast Neoplasms
T-Lymphocytes
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Splenic alterations during mammary tumorigenesis : Diverse effects on different immune parameters. / Paul, R. D.; Ghaffar, A.; Sigel, M. M.; Charyulu, V.; Lopez, Diana M.

In: Anticancer Research, Vol. 1, No. 2, 01.12.1981, p. 63-69.

Research output: Contribution to journalArticle

Paul, R. D. ; Ghaffar, A. ; Sigel, M. M. ; Charyulu, V. ; Lopez, Diana M. / Splenic alterations during mammary tumorigenesis : Diverse effects on different immune parameters. In: Anticancer Research. 1981 ; Vol. 1, No. 2. pp. 63-69.
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