Spinal cord gliomas

A multi-institutional retrospective analysis

May Abdel-Wahab, Blessing Etuk, James Palermo, Hiroki Shirato, John Kresl, Ozlem Yapicier, Gail Walker, Bernd W. Scheithauer, Edward Shaw, Charles Lee, Walter Curran, Terry Thomas, Arnold Markoe

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Purpose: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas. Patients and Methods: Data from 242 patients were collected retrospectively from six institutions using a standardized data sheet. Pathology specimens, when available, were centrally reviewed. Results: A total of 183 patients were analyzed: 82 received surgery alone as initial treatment, whereas 101 had surgery and POXRT. Demographic, diagnostic, and treatment factors were analyzed for impact on progression-free (PFS) and overall survival (OS). PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01). OS of ependymoma patients was 91%, 84%, and 75% at 5, 10, and 15 years, respectively, and was significantly influenced by both complete resection (p = 0.04) and age (p = 0.03) on MVA. In astrocytomas, PFS was 42%, 29%, and 15% at 5, 10, and 15 years, and was significantly influenced by POXRT in low- and intermediate-grade tumors on MVA (p = 0.02). OS at 5, 10, and 15 years was 59%, 53%, and 32%, respectively, and was significantly influenced by grade on MVA (p < 0.01). Conclusion: Postoperative radiation therapy reduced disease progression in low- and moderate-grade astrocytomas. In ependymomas, complete resection significantly influenced OS.

Original languageEnglish
Pages (from-to)1060-1071
Number of pages12
JournalInternational Journal of Radiation Oncology Biology Physics
Volume64
Issue number4
DOIs
StatePublished - Mar 15 2006

Fingerprint

spinal cord
Glioma
Spinal Cord
Ependymoma
grade
Multivariate Analysis
surgery
Survival
Astrocytoma
progressions
radiation therapy
Radiotherapy
tumors
pathology
Disease Progression
Neoplasms
Therapeutics
Demography
Pathology

Keywords

  • Glioma
  • Radiation
  • Spinal cord

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Spinal cord gliomas : A multi-institutional retrospective analysis. / Abdel-Wahab, May; Etuk, Blessing; Palermo, James; Shirato, Hiroki; Kresl, John; Yapicier, Ozlem; Walker, Gail; Scheithauer, Bernd W.; Shaw, Edward; Lee, Charles; Curran, Walter; Thomas, Terry; Markoe, Arnold.

In: International Journal of Radiation Oncology Biology Physics, Vol. 64, No. 4, 15.03.2006, p. 1060-1071.

Research output: Contribution to journalArticle

Abdel-Wahab, M, Etuk, B, Palermo, J, Shirato, H, Kresl, J, Yapicier, O, Walker, G, Scheithauer, BW, Shaw, E, Lee, C, Curran, W, Thomas, T & Markoe, A 2006, 'Spinal cord gliomas: A multi-institutional retrospective analysis', International Journal of Radiation Oncology Biology Physics, vol. 64, no. 4, pp. 1060-1071. https://doi.org/10.1016/j.ijrobp.2005.09.038
Abdel-Wahab, May ; Etuk, Blessing ; Palermo, James ; Shirato, Hiroki ; Kresl, John ; Yapicier, Ozlem ; Walker, Gail ; Scheithauer, Bernd W. ; Shaw, Edward ; Lee, Charles ; Curran, Walter ; Thomas, Terry ; Markoe, Arnold. / Spinal cord gliomas : A multi-institutional retrospective analysis. In: International Journal of Radiation Oncology Biology Physics. 2006 ; Vol. 64, No. 4. pp. 1060-1071.
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AU - Kresl, John

AU - Yapicier, Ozlem

AU - Walker, Gail

AU - Scheithauer, Bernd W.

AU - Shaw, Edward

AU - Lee, Charles

AU - Curran, Walter

AU - Thomas, Terry

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N2 - Purpose: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas. Patients and Methods: Data from 242 patients were collected retrospectively from six institutions using a standardized data sheet. Pathology specimens, when available, were centrally reviewed. Results: A total of 183 patients were analyzed: 82 received surgery alone as initial treatment, whereas 101 had surgery and POXRT. Demographic, diagnostic, and treatment factors were analyzed for impact on progression-free (PFS) and overall survival (OS). PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01). OS of ependymoma patients was 91%, 84%, and 75% at 5, 10, and 15 years, respectively, and was significantly influenced by both complete resection (p = 0.04) and age (p = 0.03) on MVA. In astrocytomas, PFS was 42%, 29%, and 15% at 5, 10, and 15 years, and was significantly influenced by POXRT in low- and intermediate-grade tumors on MVA (p = 0.02). OS at 5, 10, and 15 years was 59%, 53%, and 32%, respectively, and was significantly influenced by grade on MVA (p < 0.01). Conclusion: Postoperative radiation therapy reduced disease progression in low- and moderate-grade astrocytomas. In ependymomas, complete resection significantly influenced OS.

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