Spinal cord gliomas: A multi-institutional retrospective analysis

May Abdel-Wahab, Blessing Etuk, James Palermo, Hiroki Shirato, John Kresl, Ozlem Yapicier, Gail Walker, Bernd W. Scheithauer, Edward Shaw, Charles Lee, Walter Curran, Terry Thomas, Arnold Markoe

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Purpose: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas. Patients and Methods: Data from 242 patients were collected retrospectively from six institutions using a standardized data sheet. Pathology specimens, when available, were centrally reviewed. Results: A total of 183 patients were analyzed: 82 received surgery alone as initial treatment, whereas 101 had surgery and POXRT. Demographic, diagnostic, and treatment factors were analyzed for impact on progression-free (PFS) and overall survival (OS). PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01). OS of ependymoma patients was 91%, 84%, and 75% at 5, 10, and 15 years, respectively, and was significantly influenced by both complete resection (p = 0.04) and age (p = 0.03) on MVA. In astrocytomas, PFS was 42%, 29%, and 15% at 5, 10, and 15 years, and was significantly influenced by POXRT in low- and intermediate-grade tumors on MVA (p = 0.02). OS at 5, 10, and 15 years was 59%, 53%, and 32%, respectively, and was significantly influenced by grade on MVA (p < 0.01). Conclusion: Postoperative radiation therapy reduced disease progression in low- and moderate-grade astrocytomas. In ependymomas, complete resection significantly influenced OS.

Original languageEnglish (US)
Pages (from-to)1060-1071
Number of pages12
JournalInternational Journal of Radiation Oncology Biology Physics
Volume64
Issue number4
DOIs
StatePublished - Mar 15 2006

Keywords

  • Glioma
  • Radiation
  • Spinal cord

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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  • Cite this

    Abdel-Wahab, M., Etuk, B., Palermo, J., Shirato, H., Kresl, J., Yapicier, O., Walker, G., Scheithauer, B. W., Shaw, E., Lee, C., Curran, W., Thomas, T., & Markoe, A. (2006). Spinal cord gliomas: A multi-institutional retrospective analysis. International Journal of Radiation Oncology Biology Physics, 64(4), 1060-1071. https://doi.org/10.1016/j.ijrobp.2005.09.038