Spermatogenesis in cryptorchidism

Alexander I. Agoulnik, Zaohua Huang, Lydia Ferguson

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations


Cryptorchidism or undescended testis is the most frequent congenital abnormality in newborn boys. The process of testicular descent to the scrotum is controlled by hormones produced in Leydig cells, insulin-like3, and androgens. Variation in genetic and environmental factors might affect testicular descent. A failure of spermatogenesis and germ cell apoptosis resulting in infertility as well as an increased risk of neoplastic transformation of germ cell are the direct consequences of cryptorchidism in adulthood.

Original languageEnglish (US)
Title of host publicationGermline Development
Subtitle of host publicationMethods and Protocols
EditorsWai-Yee Chan, Le Ann Blomberg
Number of pages21
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Androgens
  • Cryptorchidism
  • Germ cell cancer
  • Infertility
  • Insulin-like3
  • Spermatogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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