Sperm motility in men with spinal cord injuries is enhanced by inactivating cytokines in the seminal plasma

Daniel R. Cohen, Sarmistha Basu, Josh M. Randall, Teodoro C. Aballa, Charles M Lynne, Nancy Brackett

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The goal of this study was to determine whether inactivating specific cytokines in seminal plasma improves sperm motility in men affected by spinal cord injury (SCI). For this purpose, we used monoclonal antibodies to interleukin 6 (IL6), interleukin 1 beta (IL1-β), and tumor necrosis factor alpha (TNF-α), all 3 cytokines having been previously detected at high concentrations in the seminal plasma of patients with SCI. In a group of 17 SCI men with low sperm motility (mean ± SE, 20.1% ± 3.1%), treatment with the 3 monoclonal antibodies at the median neutralization dose concentrations for 1.0 to 1.5 hours improved sperm motility in all cases. Effectiveness was higher in those specimens with a pretreatment sperm motility between 11% and 30% (from 19.3% ± 1.4% to 41.9% ± 4.9%, P < .0002), suggesting that pretreatment sperm motility might represent an indicator of cell damage and, therefore, a factor that influences monoclonal antibody effectiveness. To the best of our knowledge, these results represent the first rational treatment for improving low sperm motility in these severely affected patients.

Original languageEnglish
Pages (from-to)922-925
Number of pages4
JournalJournal of Andrology
Volume25
Issue number6
StatePublished - Nov 1 2004

Fingerprint

Sperm Motility
Semen
Spinal Cord Injuries
Cytokines
Monoclonal Antibodies
Interleukin-1beta
Interleukin-6
Tumor Necrosis Factor-alpha
Therapeutics

Keywords

  • Ejaculation
  • IL1-β
  • IL6
  • Infertility
  • Semen
  • TNF-α

ASJC Scopus subject areas

  • Endocrinology

Cite this

Cohen, D. R., Basu, S., Randall, J. M., Aballa, T. C., Lynne, C. M., & Brackett, N. (2004). Sperm motility in men with spinal cord injuries is enhanced by inactivating cytokines in the seminal plasma. Journal of Andrology, 25(6), 922-925.

Sperm motility in men with spinal cord injuries is enhanced by inactivating cytokines in the seminal plasma. / Cohen, Daniel R.; Basu, Sarmistha; Randall, Josh M.; Aballa, Teodoro C.; Lynne, Charles M; Brackett, Nancy.

In: Journal of Andrology, Vol. 25, No. 6, 01.11.2004, p. 922-925.

Research output: Contribution to journalArticle

Cohen, DR, Basu, S, Randall, JM, Aballa, TC, Lynne, CM & Brackett, N 2004, 'Sperm motility in men with spinal cord injuries is enhanced by inactivating cytokines in the seminal plasma', Journal of Andrology, vol. 25, no. 6, pp. 922-925.
Cohen, Daniel R. ; Basu, Sarmistha ; Randall, Josh M. ; Aballa, Teodoro C. ; Lynne, Charles M ; Brackett, Nancy. / Sperm motility in men with spinal cord injuries is enhanced by inactivating cytokines in the seminal plasma. In: Journal of Andrology. 2004 ; Vol. 25, No. 6. pp. 922-925.
@article{474aa587b90646dab014529c45b060f6,
title = "Sperm motility in men with spinal cord injuries is enhanced by inactivating cytokines in the seminal plasma",
abstract = "The goal of this study was to determine whether inactivating specific cytokines in seminal plasma improves sperm motility in men affected by spinal cord injury (SCI). For this purpose, we used monoclonal antibodies to interleukin 6 (IL6), interleukin 1 beta (IL1-β), and tumor necrosis factor alpha (TNF-α), all 3 cytokines having been previously detected at high concentrations in the seminal plasma of patients with SCI. In a group of 17 SCI men with low sperm motility (mean ± SE, 20.1{\%} ± 3.1{\%}), treatment with the 3 monoclonal antibodies at the median neutralization dose concentrations for 1.0 to 1.5 hours improved sperm motility in all cases. Effectiveness was higher in those specimens with a pretreatment sperm motility between 11{\%} and 30{\%} (from 19.3{\%} ± 1.4{\%} to 41.9{\%} ± 4.9{\%}, P < .0002), suggesting that pretreatment sperm motility might represent an indicator of cell damage and, therefore, a factor that influences monoclonal antibody effectiveness. To the best of our knowledge, these results represent the first rational treatment for improving low sperm motility in these severely affected patients.",
keywords = "Ejaculation, IL1-β, IL6, Infertility, Semen, TNF-α",
author = "Cohen, {Daniel R.} and Sarmistha Basu and Randall, {Josh M.} and Aballa, {Teodoro C.} and Lynne, {Charles M} and Nancy Brackett",
year = "2004",
month = "11",
day = "1",
language = "English",
volume = "25",
pages = "922--925",
journal = "Journal of Andrology",
issn = "0196-3635",
publisher = "American Society of Andrology Inc.",
number = "6",

}

TY - JOUR

T1 - Sperm motility in men with spinal cord injuries is enhanced by inactivating cytokines in the seminal plasma

AU - Cohen, Daniel R.

AU - Basu, Sarmistha

AU - Randall, Josh M.

AU - Aballa, Teodoro C.

AU - Lynne, Charles M

AU - Brackett, Nancy

PY - 2004/11/1

Y1 - 2004/11/1

N2 - The goal of this study was to determine whether inactivating specific cytokines in seminal plasma improves sperm motility in men affected by spinal cord injury (SCI). For this purpose, we used monoclonal antibodies to interleukin 6 (IL6), interleukin 1 beta (IL1-β), and tumor necrosis factor alpha (TNF-α), all 3 cytokines having been previously detected at high concentrations in the seminal plasma of patients with SCI. In a group of 17 SCI men with low sperm motility (mean ± SE, 20.1% ± 3.1%), treatment with the 3 monoclonal antibodies at the median neutralization dose concentrations for 1.0 to 1.5 hours improved sperm motility in all cases. Effectiveness was higher in those specimens with a pretreatment sperm motility between 11% and 30% (from 19.3% ± 1.4% to 41.9% ± 4.9%, P < .0002), suggesting that pretreatment sperm motility might represent an indicator of cell damage and, therefore, a factor that influences monoclonal antibody effectiveness. To the best of our knowledge, these results represent the first rational treatment for improving low sperm motility in these severely affected patients.

AB - The goal of this study was to determine whether inactivating specific cytokines in seminal plasma improves sperm motility in men affected by spinal cord injury (SCI). For this purpose, we used monoclonal antibodies to interleukin 6 (IL6), interleukin 1 beta (IL1-β), and tumor necrosis factor alpha (TNF-α), all 3 cytokines having been previously detected at high concentrations in the seminal plasma of patients with SCI. In a group of 17 SCI men with low sperm motility (mean ± SE, 20.1% ± 3.1%), treatment with the 3 monoclonal antibodies at the median neutralization dose concentrations for 1.0 to 1.5 hours improved sperm motility in all cases. Effectiveness was higher in those specimens with a pretreatment sperm motility between 11% and 30% (from 19.3% ± 1.4% to 41.9% ± 4.9%, P < .0002), suggesting that pretreatment sperm motility might represent an indicator of cell damage and, therefore, a factor that influences monoclonal antibody effectiveness. To the best of our knowledge, these results represent the first rational treatment for improving low sperm motility in these severely affected patients.

KW - Ejaculation

KW - IL1-β

KW - IL6

KW - Infertility

KW - Semen

KW - TNF-α

UR - http://www.scopus.com/inward/record.url?scp=7044264971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7044264971&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 922

EP - 925

JO - Journal of Andrology

JF - Journal of Andrology

SN - 0196-3635

IS - 6

ER -