Sperm chromosome analysis of a man heterozygous for a pericentric inversion of chromosome 3

Wayne E Balkan, K. Burns, R. H. Martin

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Using a procedure in which human sperm were allowed to fertilize zona-free golden hamster (Mesocricetus auratus) eggs in vitro, the sperm chromosomes of a man heterozygous for inv(3) (p11q11) were analyzed. When the chromosomes were Q-banded. the inverted chromosome had the bright centromeric band on the short arm rather than on the long arm, as was seen in the normal No. 3. One hundred and eleven sperm chromosome spreads were examined, of which 64 contained the normal chromosome and 47 the inverted one. This was not significantly different from the expected 1:1 ratio. No sperm containing a chromosome imbalance caused by a crossover within the inversion were seen. Ten (8.1%) of the sperm contained chromosome abnormalities unrelated to the inversion. The ratio of X- to Y-bearing sperm was 55:45.

Original languageEnglish (US)
Pages (from-to)295-297
Number of pages3
JournalCytogenetic and Genome Research
Volume35
Issue number4
StatePublished - 1983
Externally publishedYes

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Chromosomes, Human, Pair 3
Spermatozoa
Chromosomes
Mesocricetus
Herpes Zoster
Chromosome Aberrations
Eggs

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

Cite this

Sperm chromosome analysis of a man heterozygous for a pericentric inversion of chromosome 3. / Balkan, Wayne E; Burns, K.; Martin, R. H.

In: Cytogenetic and Genome Research, Vol. 35, No. 4, 1983, p. 295-297.

Research output: Contribution to journalArticle

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