Spectroscopic imaging as a triage test for cervical disease: A prospective multicenter clinical trial

Timothy DeSantis, Nahida Chakhtoura, Leo Twiggs, Daron Ferris, Manocher Lashgari, Lisa Flowers, Mark Faupel, Shabbir Bambot, Steven Raab, Edward Wilkinson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

OBJECTIVE. The objective of the study was to evaluate the potential safety and effectiveness of tissue spectroscopy for the diagnosis of cervical cancer in a prospective multicenter study of women scheduled for colposcopy on the basis of an abnormal Pap test or other risk factor. MATERIALS AND METHODS. Five hundred seventy-two women underwent spectroscopy of the cervix during their colposcopy visit. Spectroscopy measurements taken over a scan period of 4 minutes and 30 seconds were integrated by a cross-validated pattern recognition model and compared with biopsy results to yield sensitivity and specificity of cervical spectroscopy. RESULTS. The median age of subjects enrolled in the study was 27.7 years. The sensitivity of cervical spectroscopy was 95.1% with a corresponding 55.2% specificity for benign lesions. Several potential confounding factors (eg, mucous, blood, patient motion, ambient light) were examined to determine their potential impact on the accuracy of the test. Ambient light seemed to have the greatest effect, but no single factor contributed significantly to the results. The subjects did not experience any adverse events from undergoing the test. CONCLUSIONS. Spectroscopy of the cervix has the potential to accurately detect cervical moderate and high-grade dysplasia while also reducing the false-positive rate for benign cervices. The test is relatively simple to implement and was well accepted by subjects enrolled in the study.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalJournal of Lower Genital Tract Disease
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2007

Fingerprint

Triage
Multicenter Studies
Spectrum Analysis
Clinical Trials
Cervix Uteri
Colposcopy
Light
Papanicolaou Test
Uterine Cervical Neoplasms
Prospective Studies
Biopsy
Safety
Sensitivity and Specificity

Keywords

  • Cancer diagnosis
  • Cervical neoplasia
  • Spectroscopy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Spectroscopic imaging as a triage test for cervical disease : A prospective multicenter clinical trial. / DeSantis, Timothy; Chakhtoura, Nahida; Twiggs, Leo; Ferris, Daron; Lashgari, Manocher; Flowers, Lisa; Faupel, Mark; Bambot, Shabbir; Raab, Steven; Wilkinson, Edward.

In: Journal of Lower Genital Tract Disease, Vol. 11, No. 1, 01.01.2007, p. 18-24.

Research output: Contribution to journalArticle

DeSantis, T, Chakhtoura, N, Twiggs, L, Ferris, D, Lashgari, M, Flowers, L, Faupel, M, Bambot, S, Raab, S & Wilkinson, E 2007, 'Spectroscopic imaging as a triage test for cervical disease: A prospective multicenter clinical trial', Journal of Lower Genital Tract Disease, vol. 11, no. 1, pp. 18-24. https://doi.org/10.1097/01.lgt.0000230207.50495.05
DeSantis, Timothy ; Chakhtoura, Nahida ; Twiggs, Leo ; Ferris, Daron ; Lashgari, Manocher ; Flowers, Lisa ; Faupel, Mark ; Bambot, Shabbir ; Raab, Steven ; Wilkinson, Edward. / Spectroscopic imaging as a triage test for cervical disease : A prospective multicenter clinical trial. In: Journal of Lower Genital Tract Disease. 2007 ; Vol. 11, No. 1. pp. 18-24.
@article{0e9e8cd5fc644280b2fd9e141538d2da,
title = "Spectroscopic imaging as a triage test for cervical disease: A prospective multicenter clinical trial",
abstract = "OBJECTIVE. The objective of the study was to evaluate the potential safety and effectiveness of tissue spectroscopy for the diagnosis of cervical cancer in a prospective multicenter study of women scheduled for colposcopy on the basis of an abnormal Pap test or other risk factor. MATERIALS AND METHODS. Five hundred seventy-two women underwent spectroscopy of the cervix during their colposcopy visit. Spectroscopy measurements taken over a scan period of 4 minutes and 30 seconds were integrated by a cross-validated pattern recognition model and compared with biopsy results to yield sensitivity and specificity of cervical spectroscopy. RESULTS. The median age of subjects enrolled in the study was 27.7 years. The sensitivity of cervical spectroscopy was 95.1{\%} with a corresponding 55.2{\%} specificity for benign lesions. Several potential confounding factors (eg, mucous, blood, patient motion, ambient light) were examined to determine their potential impact on the accuracy of the test. Ambient light seemed to have the greatest effect, but no single factor contributed significantly to the results. The subjects did not experience any adverse events from undergoing the test. CONCLUSIONS. Spectroscopy of the cervix has the potential to accurately detect cervical moderate and high-grade dysplasia while also reducing the false-positive rate for benign cervices. The test is relatively simple to implement and was well accepted by subjects enrolled in the study.",
keywords = "Cancer diagnosis, Cervical neoplasia, Spectroscopy",
author = "Timothy DeSantis and Nahida Chakhtoura and Leo Twiggs and Daron Ferris and Manocher Lashgari and Lisa Flowers and Mark Faupel and Shabbir Bambot and Steven Raab and Edward Wilkinson",
year = "2007",
month = "1",
day = "1",
doi = "10.1097/01.lgt.0000230207.50495.05",
language = "English",
volume = "11",
pages = "18--24",
journal = "Journal of Lower Genital Tract Disease",
issn = "1089-2591",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Spectroscopic imaging as a triage test for cervical disease

T2 - A prospective multicenter clinical trial

AU - DeSantis, Timothy

AU - Chakhtoura, Nahida

AU - Twiggs, Leo

AU - Ferris, Daron

AU - Lashgari, Manocher

AU - Flowers, Lisa

AU - Faupel, Mark

AU - Bambot, Shabbir

AU - Raab, Steven

AU - Wilkinson, Edward

PY - 2007/1/1

Y1 - 2007/1/1

N2 - OBJECTIVE. The objective of the study was to evaluate the potential safety and effectiveness of tissue spectroscopy for the diagnosis of cervical cancer in a prospective multicenter study of women scheduled for colposcopy on the basis of an abnormal Pap test or other risk factor. MATERIALS AND METHODS. Five hundred seventy-two women underwent spectroscopy of the cervix during their colposcopy visit. Spectroscopy measurements taken over a scan period of 4 minutes and 30 seconds were integrated by a cross-validated pattern recognition model and compared with biopsy results to yield sensitivity and specificity of cervical spectroscopy. RESULTS. The median age of subjects enrolled in the study was 27.7 years. The sensitivity of cervical spectroscopy was 95.1% with a corresponding 55.2% specificity for benign lesions. Several potential confounding factors (eg, mucous, blood, patient motion, ambient light) were examined to determine their potential impact on the accuracy of the test. Ambient light seemed to have the greatest effect, but no single factor contributed significantly to the results. The subjects did not experience any adverse events from undergoing the test. CONCLUSIONS. Spectroscopy of the cervix has the potential to accurately detect cervical moderate and high-grade dysplasia while also reducing the false-positive rate for benign cervices. The test is relatively simple to implement and was well accepted by subjects enrolled in the study.

AB - OBJECTIVE. The objective of the study was to evaluate the potential safety and effectiveness of tissue spectroscopy for the diagnosis of cervical cancer in a prospective multicenter study of women scheduled for colposcopy on the basis of an abnormal Pap test or other risk factor. MATERIALS AND METHODS. Five hundred seventy-two women underwent spectroscopy of the cervix during their colposcopy visit. Spectroscopy measurements taken over a scan period of 4 minutes and 30 seconds were integrated by a cross-validated pattern recognition model and compared with biopsy results to yield sensitivity and specificity of cervical spectroscopy. RESULTS. The median age of subjects enrolled in the study was 27.7 years. The sensitivity of cervical spectroscopy was 95.1% with a corresponding 55.2% specificity for benign lesions. Several potential confounding factors (eg, mucous, blood, patient motion, ambient light) were examined to determine their potential impact on the accuracy of the test. Ambient light seemed to have the greatest effect, but no single factor contributed significantly to the results. The subjects did not experience any adverse events from undergoing the test. CONCLUSIONS. Spectroscopy of the cervix has the potential to accurately detect cervical moderate and high-grade dysplasia while also reducing the false-positive rate for benign cervices. The test is relatively simple to implement and was well accepted by subjects enrolled in the study.

KW - Cancer diagnosis

KW - Cervical neoplasia

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=33845975662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845975662&partnerID=8YFLogxK

U2 - 10.1097/01.lgt.0000230207.50495.05

DO - 10.1097/01.lgt.0000230207.50495.05

M3 - Article

C2 - 17194946

AN - SCOPUS:33845975662

VL - 11

SP - 18

EP - 24

JO - Journal of Lower Genital Tract Disease

JF - Journal of Lower Genital Tract Disease

SN - 1089-2591

IS - 1

ER -