Spectral-domain optical coherence tomography measurements of choroidal thickness and outer retinal disruption in macular telangiectasia type 2

Renata Portella Nunes, Raquel Goldhardt, Carlos Alexandre De Amorim Garcia Filho, Mariana R. Thorell, Ashkan M. Abbey, Ajay E. Kuriyan, Yasha S. Modi, Milan Shah, Zohar Yehoshua, Giovanni Gregori, William Feuer, Philip J. Rosenfeld

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

BACKGROUND AND OBJECTIVE: To evaluate subfoveal choroidal thickness (CT) and the extent of outer retinal disruption in patients with macular telangiectasia type 2 (MacTel2) compared with healthy eyes. PATIENTS AND METHODS: In this prospective, observational, cohort study, 62 patients (62 eyes) with Mac-Tel2 and 130 healthy controls (130 eyes) underwent a complete ophthalmological examination, spectraldomain optical coherence tomography (SD-OCT) imaging, and axial length measurements. Patients in the study group also underwent color fundus photography, fundus autofluorescence, and fluorescein angiography. En face SD-OCT imaging was used to assess abnormalities involving the photoreceptor inner segment/ outer segment/ellipsoid zone (IS/OS/EZ). RESULTS: After adjusting for age and axial length, the authors found that eyes with MacTel2 had a mean CT measurement that was greater than control eyes (P = .007). There was a negative correlation between the visual acuity and the area of IS/OS/EZ damage (P = .009), but no statistically significant correlation was seen between CT and the area of IS/OS/EZ damage. CONCLUSION: Eyes with MacTel2 were found to have thicker CT measurements than control eyes. While the extent of IS/OS/EZ disruption correlated with the loss of visual acuity, this damage did not correlate with CT measurements.

Original languageEnglish (US)
Pages (from-to)162-170
Number of pages9
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume46
Issue number2
DOIs
StatePublished - Feb 1 2015

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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