Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease

A. M. Saunders, C. Hulette, K. A. Welsh-Bohmer, D. E. Schmechel, B. Crain, J. R. Burke, M. J. Alberts, W. J. Strittmatter, J. C S Breitner, C. Rosenberg, S. V. Scott, P. C. Gaskell, Margaret A Pericak-Vance, A. D. Roses

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Abstract

Background: We aimed to determine the specificity, sensitivity, and predictive value of apolipoprotein E (APOE) genotyping in 67 consecutive patients with clinical diagnoses of sporadic Alzheimer's disease (AD) who underwent necropsy. Methods: We studied patients who attended the Duke Memory Disorders Clinic and were diagnosed as having probable AD. These patients were followed up until they died. APOE genotyping was done during life in most cases, but in some brain tissue obtained at necropsy was used. Members of known AD families were excluded. Findings: After neuropathological examination 57 (85%) of 67 of our patients were confirmed as having AD including all 43 who had at least one APOE-ε4 allele. None of the patients found not to have AD carried an ε4 allele. In this series, the specificity of the ε4 allele was 100%, the sensitivity 75%, the positive predictive value 100%, and the negative predictive value 42%. In this necropsy-confirmed series, the ε4/ε4 genotype predicted AD with 100% accuracy. The ε3/ε4 and ε2/ε4 genotypes were also unexpectedly highly specific for AD. Interpretation: Data from hundreds of necropsy-confirmed non-AD patients in other longitudinal necropsy series will allow the predictive value of APOE genotypes to be assessed with useful confidence limits.

Original languageEnglish
Pages (from-to)90-93
Number of pages4
JournalLancet
Volume348
Issue number9020
DOIs
StatePublished - Jul 13 1996
Externally publishedYes

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Apolipoproteins E
Alzheimer Disease
Sensitivity and Specificity
Alleles
Genotype
Apolipoprotein E4
Memory Disorders
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Saunders, A. M., Hulette, C., Welsh-Bohmer, K. A., Schmechel, D. E., Crain, B., Burke, J. R., ... Roses, A. D. (1996). Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet, 348(9020), 90-93. https://doi.org/10.1016/S0140-6736(96)01251-2

Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. / Saunders, A. M.; Hulette, C.; Welsh-Bohmer, K. A.; Schmechel, D. E.; Crain, B.; Burke, J. R.; Alberts, M. J.; Strittmatter, W. J.; Breitner, J. C S; Rosenberg, C.; Scott, S. V.; Gaskell, P. C.; Pericak-Vance, Margaret A; Roses, A. D.

In: Lancet, Vol. 348, No. 9020, 13.07.1996, p. 90-93.

Research output: Contribution to journalArticle

Saunders, AM, Hulette, C, Welsh-Bohmer, KA, Schmechel, DE, Crain, B, Burke, JR, Alberts, MJ, Strittmatter, WJ, Breitner, JCS, Rosenberg, C, Scott, SV, Gaskell, PC, Pericak-Vance, MA & Roses, AD 1996, 'Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease', Lancet, vol. 348, no. 9020, pp. 90-93. https://doi.org/10.1016/S0140-6736(96)01251-2
Saunders AM, Hulette C, Welsh-Bohmer KA, Schmechel DE, Crain B, Burke JR et al. Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet. 1996 Jul 13;348(9020):90-93. https://doi.org/10.1016/S0140-6736(96)01251-2
Saunders, A. M. ; Hulette, C. ; Welsh-Bohmer, K. A. ; Schmechel, D. E. ; Crain, B. ; Burke, J. R. ; Alberts, M. J. ; Strittmatter, W. J. ; Breitner, J. C S ; Rosenberg, C. ; Scott, S. V. ; Gaskell, P. C. ; Pericak-Vance, Margaret A ; Roses, A. D. / Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. In: Lancet. 1996 ; Vol. 348, No. 9020. pp. 90-93.
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AU - Crain, B.

AU - Burke, J. R.

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AU - Scott, S. V.

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AU - Pericak-Vance, Margaret A

AU - Roses, A. D.

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