Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

E. Ruberte, P. Dolle, A. Krust, Arthur Z Zelent, G. Morriss-Kay, P. Chambon

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

Retinoic acid (RA), a putative morphogen in vertebrates, has profound effects on development during embryogenesis, chondrogenesis and differentiation of squamous epithelia. The distribution of the transcripts of the retinoic acid receptor gamma (RAR-γ) gene has been studied here by in situ hybridization during mouse development from days 6.5 to 15.5 post-coitum (p.c.). RAR-γ transcripts are detected as early as day 8 p.c. in the presomitic posterior region. Between days 9.5 and 11.5 p.c., the transcripts are uniformly distributed in the mesenchyme of the frontonasal region, pharyngeal arches, limb buds and sclerotomes. At day 12.5 p.c., RAR-γ transcripts are found in all precartilaginous mesenchymal condensations. From day 13.5 p.c., the transcripts are specifically localized in all cartilages and differentiating squamous keratinizing epithelia, irrespective of their embryological origin. RAR-γ transcripts are also found in the developing teeth and whisker follicles. The developmental pattern of expression of the RAR-γ gene suggests that RAR-γ plays a crucial role for transducing RA signals at the level of gene expression during morphogenesis, chondrogenesis and differentiation of squamous epithelia.

Original languageEnglish (US)
Pages (from-to)213-222
Number of pages10
JournalDevelopment
Volume108
Issue number2
StatePublished - Mar 19 1990
Externally publishedYes

Fingerprint

Embryonic Development
Chondrogenesis
Epithelium
Tretinoin
Branchial Region
Limb Buds
Vibrissae
Mesoderm
Morphogenesis
Genes
Cartilage
In Situ Hybridization
Vertebrates
retinoic acid receptor gamma
Tooth
Gene Expression

Keywords

  • Cartilage
  • Development
  • In situ hybridization
  • RAR-γ
  • Squamous epithelia

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Cite this

Ruberte, E., Dolle, P., Krust, A., Zelent, A. Z., Morriss-Kay, G., & Chambon, P. (1990). Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis. Development, 108(2), 213-222.

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis. / Ruberte, E.; Dolle, P.; Krust, A.; Zelent, Arthur Z; Morriss-Kay, G.; Chambon, P.

In: Development, Vol. 108, No. 2, 19.03.1990, p. 213-222.

Research output: Contribution to journalArticle

Ruberte, E, Dolle, P, Krust, A, Zelent, AZ, Morriss-Kay, G & Chambon, P 1990, 'Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis', Development, vol. 108, no. 2, pp. 213-222.
Ruberte E, Dolle P, Krust A, Zelent AZ, Morriss-Kay G, Chambon P. Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis. Development. 1990 Mar 19;108(2):213-222.
Ruberte, E. ; Dolle, P. ; Krust, A. ; Zelent, Arthur Z ; Morriss-Kay, G. ; Chambon, P. / Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis. In: Development. 1990 ; Vol. 108, No. 2. pp. 213-222.
@article{27ccfe85eca44e8baa416756e58ba466,
title = "Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis",
abstract = "Retinoic acid (RA), a putative morphogen in vertebrates, has profound effects on development during embryogenesis, chondrogenesis and differentiation of squamous epithelia. The distribution of the transcripts of the retinoic acid receptor gamma (RAR-γ) gene has been studied here by in situ hybridization during mouse development from days 6.5 to 15.5 post-coitum (p.c.). RAR-γ transcripts are detected as early as day 8 p.c. in the presomitic posterior region. Between days 9.5 and 11.5 p.c., the transcripts are uniformly distributed in the mesenchyme of the frontonasal region, pharyngeal arches, limb buds and sclerotomes. At day 12.5 p.c., RAR-γ transcripts are found in all precartilaginous mesenchymal condensations. From day 13.5 p.c., the transcripts are specifically localized in all cartilages and differentiating squamous keratinizing epithelia, irrespective of their embryological origin. RAR-γ transcripts are also found in the developing teeth and whisker follicles. The developmental pattern of expression of the RAR-γ gene suggests that RAR-γ plays a crucial role for transducing RA signals at the level of gene expression during morphogenesis, chondrogenesis and differentiation of squamous epithelia.",
keywords = "Cartilage, Development, In situ hybridization, RAR-γ, Squamous epithelia",
author = "E. Ruberte and P. Dolle and A. Krust and Zelent, {Arthur Z} and G. Morriss-Kay and P. Chambon",
year = "1990",
month = "3",
day = "19",
language = "English (US)",
volume = "108",
pages = "213--222",
journal = "Development (Cambridge)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "2",

}

TY - JOUR

T1 - Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

AU - Ruberte, E.

AU - Dolle, P.

AU - Krust, A.

AU - Zelent, Arthur Z

AU - Morriss-Kay, G.

AU - Chambon, P.

PY - 1990/3/19

Y1 - 1990/3/19

N2 - Retinoic acid (RA), a putative morphogen in vertebrates, has profound effects on development during embryogenesis, chondrogenesis and differentiation of squamous epithelia. The distribution of the transcripts of the retinoic acid receptor gamma (RAR-γ) gene has been studied here by in situ hybridization during mouse development from days 6.5 to 15.5 post-coitum (p.c.). RAR-γ transcripts are detected as early as day 8 p.c. in the presomitic posterior region. Between days 9.5 and 11.5 p.c., the transcripts are uniformly distributed in the mesenchyme of the frontonasal region, pharyngeal arches, limb buds and sclerotomes. At day 12.5 p.c., RAR-γ transcripts are found in all precartilaginous mesenchymal condensations. From day 13.5 p.c., the transcripts are specifically localized in all cartilages and differentiating squamous keratinizing epithelia, irrespective of their embryological origin. RAR-γ transcripts are also found in the developing teeth and whisker follicles. The developmental pattern of expression of the RAR-γ gene suggests that RAR-γ plays a crucial role for transducing RA signals at the level of gene expression during morphogenesis, chondrogenesis and differentiation of squamous epithelia.

AB - Retinoic acid (RA), a putative morphogen in vertebrates, has profound effects on development during embryogenesis, chondrogenesis and differentiation of squamous epithelia. The distribution of the transcripts of the retinoic acid receptor gamma (RAR-γ) gene has been studied here by in situ hybridization during mouse development from days 6.5 to 15.5 post-coitum (p.c.). RAR-γ transcripts are detected as early as day 8 p.c. in the presomitic posterior region. Between days 9.5 and 11.5 p.c., the transcripts are uniformly distributed in the mesenchyme of the frontonasal region, pharyngeal arches, limb buds and sclerotomes. At day 12.5 p.c., RAR-γ transcripts are found in all precartilaginous mesenchymal condensations. From day 13.5 p.c., the transcripts are specifically localized in all cartilages and differentiating squamous keratinizing epithelia, irrespective of their embryological origin. RAR-γ transcripts are also found in the developing teeth and whisker follicles. The developmental pattern of expression of the RAR-γ gene suggests that RAR-γ plays a crucial role for transducing RA signals at the level of gene expression during morphogenesis, chondrogenesis and differentiation of squamous epithelia.

KW - Cartilage

KW - Development

KW - In situ hybridization

KW - RAR-γ

KW - Squamous epithelia

UR - http://www.scopus.com/inward/record.url?scp=0025177085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025177085&partnerID=8YFLogxK

M3 - Article

C2 - 2161730

AN - SCOPUS:0025177085

VL - 108

SP - 213

EP - 222

JO - Development (Cambridge)

JF - Development (Cambridge)

SN - 0950-1991

IS - 2

ER -