Specific nutrient abnormalities in asymptomatic HIV-1 infection

Richard S. Beach, Emilio Mantero-Atienza, Gail Shor-Posner, Julian J. Javier, Jose Szapocznik, Robert Morgan, Howerde E. Sauberlich, Phillip E. Cornwell, Carl Eisdorfer, Marianna K. Baum

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

Objective: To determine whether specific nutrient abnormalities occur in earlier stages of HIV-1 infection, thereby preceding the marked wasting and malnutrition that accompany later stages of the infection. Design: A longitudinal investigation to determine biological, psychological and social factors thought to influence the progression and outcome of HIV-1 infection. Nutritional status was assessed using biochemical measurement of nutrient levels, dietary history, anthropometry and clinical examination for the signs and symptoms of nutritional deficiency or excess. Setting: The study was performed on an outpatient basis at the University of Miami School of Medicine. Participants: One hundred homosexual men, aged between 20 and 55 years, who were asymptomatic other than persistent generalized lymphadenopathy (Centers for Disease Control stage III) and 42 age-matched homosexual men demonstrated to be free of HIV-1 infection at two 6-month intervals. Main outcome measures: Biochemical measurement of nutrient status, dietary history, anthropometry, clinical signs or symptoms of nutritional excess or deficiency were obtained for all participants. Results: Despite few differences in mean blood levels of specific nutrients, prevalence of specific nutrient abnormalities was widespread among HIV-1-infected subjects, compared with non-infected male homosexual controls. Overtly and marginally low blood levels of vitamins A (18%), E (27%), riboflavin (26%), B6 (53%), and B12 (23%), together with copper (74%) and zinc (50%) were documented in HIV-1-seropositive subjects. With the exception of riboflavin, zinc, and copper, a similar prevalence of abnormalities among HIV-1-seronegative controls was not observed. Conclusion: Specific nutrient abnormalities occur with relative frequency in asymptomatic HIV-1 infection and may contribute to the rate and form of HIV-1 disease progression.

Original languageEnglish
Pages (from-to)701-708
Number of pages8
JournalAIDS
Volume6
Issue number7
StatePublished - Jul 1 1992

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HIV Infections
HIV-1
Food
Anthropometry
Riboflavin
Malnutrition
Signs and Symptoms
Zinc
Copper
Centers for Disease Control and Prevention (U.S.)
Nutritional Status
Vitamin A
Disease Progression
Outpatients
Medicine
Outcome Assessment (Health Care)
Psychology
Infection
Sexual Minorities

Keywords

  • Copper
  • HIV-1 infection
  • Nutrition
  • Riboflavin
  • Vitamin A
  • Vitamin B
  • Vitamin B
  • Vitamin E
  • Zinc

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Beach, R. S., Mantero-Atienza, E., Shor-Posner, G., Javier, J. J., Szapocznik, J., Morgan, R., ... Baum, M. K. (1992). Specific nutrient abnormalities in asymptomatic HIV-1 infection. AIDS, 6(7), 701-708.

Specific nutrient abnormalities in asymptomatic HIV-1 infection. / Beach, Richard S.; Mantero-Atienza, Emilio; Shor-Posner, Gail; Javier, Julian J.; Szapocznik, Jose; Morgan, Robert; Sauberlich, Howerde E.; Cornwell, Phillip E.; Eisdorfer, Carl; Baum, Marianna K.

In: AIDS, Vol. 6, No. 7, 01.07.1992, p. 701-708.

Research output: Contribution to journalArticle

Beach, RS, Mantero-Atienza, E, Shor-Posner, G, Javier, JJ, Szapocznik, J, Morgan, R, Sauberlich, HE, Cornwell, PE, Eisdorfer, C & Baum, MK 1992, 'Specific nutrient abnormalities in asymptomatic HIV-1 infection', AIDS, vol. 6, no. 7, pp. 701-708.
Beach RS, Mantero-Atienza E, Shor-Posner G, Javier JJ, Szapocznik J, Morgan R et al. Specific nutrient abnormalities in asymptomatic HIV-1 infection. AIDS. 1992 Jul 1;6(7):701-708.
Beach, Richard S. ; Mantero-Atienza, Emilio ; Shor-Posner, Gail ; Javier, Julian J. ; Szapocznik, Jose ; Morgan, Robert ; Sauberlich, Howerde E. ; Cornwell, Phillip E. ; Eisdorfer, Carl ; Baum, Marianna K. / Specific nutrient abnormalities in asymptomatic HIV-1 infection. In: AIDS. 1992 ; Vol. 6, No. 7. pp. 701-708.
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abstract = "Objective: To determine whether specific nutrient abnormalities occur in earlier stages of HIV-1 infection, thereby preceding the marked wasting and malnutrition that accompany later stages of the infection. Design: A longitudinal investigation to determine biological, psychological and social factors thought to influence the progression and outcome of HIV-1 infection. Nutritional status was assessed using biochemical measurement of nutrient levels, dietary history, anthropometry and clinical examination for the signs and symptoms of nutritional deficiency or excess. Setting: The study was performed on an outpatient basis at the University of Miami School of Medicine. Participants: One hundred homosexual men, aged between 20 and 55 years, who were asymptomatic other than persistent generalized lymphadenopathy (Centers for Disease Control stage III) and 42 age-matched homosexual men demonstrated to be free of HIV-1 infection at two 6-month intervals. Main outcome measures: Biochemical measurement of nutrient status, dietary history, anthropometry, clinical signs or symptoms of nutritional excess or deficiency were obtained for all participants. Results: Despite few differences in mean blood levels of specific nutrients, prevalence of specific nutrient abnormalities was widespread among HIV-1-infected subjects, compared with non-infected male homosexual controls. Overtly and marginally low blood levels of vitamins A (18{\%}), E (27{\%}), riboflavin (26{\%}), B6 (53{\%}), and B12 (23{\%}), together with copper (74{\%}) and zinc (50{\%}) were documented in HIV-1-seropositive subjects. With the exception of riboflavin, zinc, and copper, a similar prevalence of abnormalities among HIV-1-seronegative controls was not observed. Conclusion: Specific nutrient abnormalities occur with relative frequency in asymptomatic HIV-1 infection and may contribute to the rate and form of HIV-1 disease progression.",
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AU - Morgan, Robert

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AU - Eisdorfer, Carl

AU - Baum, Marianna K.

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N2 - Objective: To determine whether specific nutrient abnormalities occur in earlier stages of HIV-1 infection, thereby preceding the marked wasting and malnutrition that accompany later stages of the infection. Design: A longitudinal investigation to determine biological, psychological and social factors thought to influence the progression and outcome of HIV-1 infection. Nutritional status was assessed using biochemical measurement of nutrient levels, dietary history, anthropometry and clinical examination for the signs and symptoms of nutritional deficiency or excess. Setting: The study was performed on an outpatient basis at the University of Miami School of Medicine. Participants: One hundred homosexual men, aged between 20 and 55 years, who were asymptomatic other than persistent generalized lymphadenopathy (Centers for Disease Control stage III) and 42 age-matched homosexual men demonstrated to be free of HIV-1 infection at two 6-month intervals. Main outcome measures: Biochemical measurement of nutrient status, dietary history, anthropometry, clinical signs or symptoms of nutritional excess or deficiency were obtained for all participants. Results: Despite few differences in mean blood levels of specific nutrients, prevalence of specific nutrient abnormalities was widespread among HIV-1-infected subjects, compared with non-infected male homosexual controls. Overtly and marginally low blood levels of vitamins A (18%), E (27%), riboflavin (26%), B6 (53%), and B12 (23%), together with copper (74%) and zinc (50%) were documented in HIV-1-seropositive subjects. With the exception of riboflavin, zinc, and copper, a similar prevalence of abnormalities among HIV-1-seronegative controls was not observed. Conclusion: Specific nutrient abnormalities occur with relative frequency in asymptomatic HIV-1 infection and may contribute to the rate and form of HIV-1 disease progression.

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