Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells

Marc E. Lippman, Hoan M. Do, Richard B. Hochberg

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.

Original languageEnglish (US)
Pages (from-to)3150-3154
Number of pages5
JournalCancer Research
Volume41
Issue number8
StatePublished - Aug 1 1981

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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