Abstract
16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.
Original language | English (US) |
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Pages (from-to) | 3150-3154 |
Number of pages | 5 |
Journal | Cancer Research |
Volume | 41 |
Issue number | 8 |
State | Published - Aug 1 1981 |
ASJC Scopus subject areas
- Oncology
- Cancer Research