Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells

Marc E. Lippman; Hoan M. Do; Richard B. Hochberg

Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells

Marc E. Lippman, Hoan M. Do, Richard B. Hochberg

Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[¹²⁵I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.

Original language	English (US)
Pages (from-to)	3150-3154
Number of pages	5
Journal	Cancer Research
Volume	41
Issue number	8
State	Published - Aug 1 1981

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

Fingerprint Dive into the research topics of 'Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells'. Together they form a unique fingerprint.

Cite this

@article{5aa9e793e332428c8ea531606371508a,

title = "Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells",

abstract = "16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.",

author = "Lippman, {Marc E.} and Do, {Hoan M.} and Hochberg, {Richard B.}",

year = "1981",

month = aug,

day = "1",

language = "English (US)",

volume = "41",

pages = "3150--3154",

journal = "Cancer Research",

issn = "0008-5472",

number = "8",

}

TY - JOUR

T1 - Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells

AU - Lippman, Marc E.

AU - Do, Hoan M.

AU - Hochberg, Richard B.

PY - 1981/8/1

Y1 - 1981/8/1

N2 - 16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.

AB - 16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=0019502912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019502912&partnerID=8YFLogxK

M3 - Article

C2 - 7248972

AN - SCOPUS:0019502912

VL - 41

SP - 3150

EP - 3154

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 8

ER -