Abstract
16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3150-3154 |
| Number of pages | 5 |
| Journal | Cancer Research |
| Volume | 41 |
| Issue number | 8 |
| State | Published - Aug 1 1981 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Cite this
Lippman, M. E., Do, H. M., & Hochberg, R. B. (1981). Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells. Cancer Research, 41(8), 3150-3154.