Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells

Marc E. Lippman; Hoan M. Do; Richard B. Hochberg

Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells

Marc E. Lippman, Hoan M. Do, Richard B. Hochberg

Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[¹²⁵I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.

Original language	English (US)
Pages (from-to)	3150-3154
Number of pages	5
Journal	Cancer Research
Volume	41
Issue number	8
State	Published - Aug 1 1981

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.",

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AU - Do, Hoan M.

AU - Hochberg, Richard B.

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AB - 16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.

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Specific Estrogen Receptor Binding and Biological Effects of 16a-lodoestradiol on Human Breast Cancer Cells

Abstract

ASJC Scopus subject areas

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