Specific estrogen receptor binding and biological effects of 16α-Iodoestradiol on human breast cancer cells

Marc E Lippman, H. M T Do, R. B. Hochberg

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

16α-Iodoestradiol was evaluated as an estrogen in MCF-7 and ZR-75-1 human breast cancer cells, 16α-[125I]Iodoestradiol binds to equivalent numbers of specific estrogen receptors with a comparable binding affinity and similar sucrose density gradient behavior. 16α-Iodoestradiol translocates receptor sites to the nucleus and induces a full range of estrogenic effects including thymidine incorporation, cell growth, and progesterone receptor. Because of its high specific activity, this compound may have unique applications on imaging of estrogen receptor-containing cells and specific receptor-mediated cytotoxicity.

Original languageEnglish
Pages (from-to)3150-3154
Number of pages5
JournalCancer Research
Volume41
Issue number8
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

Estrogen Receptors
Breast Neoplasms
Estrogens
Progesterone Receptors
Thymidine
Sucrose
Growth
16 alpha-iodoestradiol

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Specific estrogen receptor binding and biological effects of 16α-Iodoestradiol on human breast cancer cells. / Lippman, Marc E; Do, H. M T; Hochberg, R. B.

In: Cancer Research, Vol. 41, No. 8, 01.01.1981, p. 3150-3154.

Research output: Contribution to journalArticle

Lippman, Marc E ; Do, H. M T ; Hochberg, R. B. / Specific estrogen receptor binding and biological effects of 16α-Iodoestradiol on human breast cancer cells. In: Cancer Research. 1981 ; Vol. 41, No. 8. pp. 3150-3154.
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