Spatially resolved derivatization of solid-phase-synthesis beads with fluorescent dendrimers

Creation of localized microdomains

Claudia M. Cardona, Stephan H. Jannach, Hao Huang, Yukiko Itojima, Roger Leblanc, Robert E. Gawley, Gary A. Baker, Eric B. Brauns

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Second and third generation Newkome-type trifurcated dendrimers, containing either a coumarin or dansyl fluorescent probe at the dendrimer core, have been synthesized and attached to ArgoGel® solid-phase-synthesis beads. Subsequent reaction with rhodamine dye shows that the dye can penetrate throughout the beads to acylate the remaining sites. Thus, it is possible to achieve a spatially resolved microdomain for library formation at the core of the dendrimer, primarily on the bead's periphery, and a second microdomain suitable for derivatization by other reagents such as encoding tags and fluorescent sensors.

Original languageEnglish
Pages (from-to)3532-3558
Number of pages27
JournalHelvetica Chimica Acta
Volume85
Issue number10
DOIs
StatePublished - Nov 26 2002

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Dendrimers
Solid-Phase Synthesis Techniques
dendrimers
beads
solid phases
Coloring Agents
synthesis
Dyes
dyes
Rhodamines
rhodamine
Fluorescent Dyes
Libraries
reagents
coding
probes
sensors
Sensors

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Spatially resolved derivatization of solid-phase-synthesis beads with fluorescent dendrimers : Creation of localized microdomains. / Cardona, Claudia M.; Jannach, Stephan H.; Huang, Hao; Itojima, Yukiko; Leblanc, Roger; Gawley, Robert E.; Baker, Gary A.; Brauns, Eric B.

In: Helvetica Chimica Acta, Vol. 85, No. 10, 26.11.2002, p. 3532-3558.

Research output: Contribution to journalArticle

Cardona, Claudia M. ; Jannach, Stephan H. ; Huang, Hao ; Itojima, Yukiko ; Leblanc, Roger ; Gawley, Robert E. ; Baker, Gary A. ; Brauns, Eric B. / Spatially resolved derivatization of solid-phase-synthesis beads with fluorescent dendrimers : Creation of localized microdomains. In: Helvetica Chimica Acta. 2002 ; Vol. 85, No. 10. pp. 3532-3558.
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