Spatially resolved derivatization of solid-phase-synthesis beads with fluorescent dendrimers: Creation of localized microdomains

Claudia M. Cardona, Stephan H. Jannach, Hao Huang, Yukiko Itojima, Roger M. Leblanc, Robert E. Gawley, Gary A. Baker, Eric B. Brauns

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Second and third generation Newkome-type trifurcated dendrimers, containing either a coumarin or dansyl fluorescent probe at the dendrimer core, have been synthesized and attached to ArgoGel® solid-phase-synthesis beads. Subsequent reaction with rhodamine dye shows that the dye can penetrate throughout the beads to acylate the remaining sites. Thus, it is possible to achieve a spatially resolved microdomain for library formation at the core of the dendrimer, primarily on the bead's periphery, and a second microdomain suitable for derivatization by other reagents such as encoding tags and fluorescent sensors.

Original languageEnglish (US)
Pages (from-to)3532-3558
Number of pages27
JournalHelvetica Chimica Acta
Volume85
Issue number10
DOIs
StatePublished - Nov 26 2002

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ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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