Spatial relationship of glioma volume derived from 18F-FET PET and volumetric MR spectroscopy imaging: A hybrid PET/MRI study

Jörg Mauler, Andrew A Maudsley, Karl Josef Langen, Omid Nikoubashman, Gabriele Stoffels, Sulaiman Sheriff, Philipp Lohmann, Christian Filss, Norbert Galldiks, Elena Rota Kops, N. Jon Shah

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

PET imaging of amino acid transport using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) May provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. Methods: In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in 18F-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Results: The average tumor volumes for 18F-FET uptake and increased Cho/NAA were 19 ± 20 cm3 (mean ± SD) and 22 ± 24 cm3, respectively, with an overlap of 40% ± 25% and separation of the centers of mass by 9 ± 8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion: 18F-FET uptake and increased Cho/NAA ratio are not always congruent and May represent different properties of glioma metabolism. The relationship to histologic tumor extent needs to be further analyzed.

Original languageEnglish (US)
Pages (from-to)603-609
Number of pages7
JournalJournal of Nuclear Medicine
Volume59
Issue number4
DOIs
StatePublished - Apr 1 2018

Fingerprint

Multimodal Imaging
Choline
Glioma
Magnetic Resonance Spectroscopy
Neoplasms
Tumor Burden
Protons
Prospective Studies
Biopsy
Amino Acids
O-(2-fluoroethyl)tyrosine
N-acetylaspartate

Keywords

  • 18F-FET
  • Congruency
  • Glioma
  • MRSI
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Spatial relationship of glioma volume derived from 18F-FET PET and volumetric MR spectroscopy imaging : A hybrid PET/MRI study. / Mauler, Jörg; Maudsley, Andrew A; Langen, Karl Josef; Nikoubashman, Omid; Stoffels, Gabriele; Sheriff, Sulaiman; Lohmann, Philipp; Filss, Christian; Galldiks, Norbert; Kops, Elena Rota; Jon Shah, N.

In: Journal of Nuclear Medicine, Vol. 59, No. 4, 01.04.2018, p. 603-609.

Research output: Contribution to journalArticle

Mauler, J, Maudsley, AA, Langen, KJ, Nikoubashman, O, Stoffels, G, Sheriff, S, Lohmann, P, Filss, C, Galldiks, N, Kops, ER & Jon Shah, N 2018, 'Spatial relationship of glioma volume derived from 18F-FET PET and volumetric MR spectroscopy imaging: A hybrid PET/MRI study', Journal of Nuclear Medicine, vol. 59, no. 4, pp. 603-609. https://doi.org/10.2967/jnumed.117.196709
Mauler, Jörg ; Maudsley, Andrew A ; Langen, Karl Josef ; Nikoubashman, Omid ; Stoffels, Gabriele ; Sheriff, Sulaiman ; Lohmann, Philipp ; Filss, Christian ; Galldiks, Norbert ; Kops, Elena Rota ; Jon Shah, N. / Spatial relationship of glioma volume derived from 18F-FET PET and volumetric MR spectroscopy imaging : A hybrid PET/MRI study. In: Journal of Nuclear Medicine. 2018 ; Vol. 59, No. 4. pp. 603-609.
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abstract = "PET imaging of amino acid transport using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) May provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. Methods: In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in 18F-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Results: The average tumor volumes for 18F-FET uptake and increased Cho/NAA were 19 ± 20 cm3 (mean ± SD) and 22 ± 24 cm3, respectively, with an overlap of 40{\%} ± 25{\%} and separation of the centers of mass by 9 ± 8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion: 18F-FET uptake and increased Cho/NAA ratio are not always congruent and May represent different properties of glioma metabolism. The relationship to histologic tumor extent needs to be further analyzed.",
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T1 - Spatial relationship of glioma volume derived from 18F-FET PET and volumetric MR spectroscopy imaging

T2 - A hybrid PET/MRI study

AU - Mauler, Jörg

AU - Maudsley, Andrew A

AU - Langen, Karl Josef

AU - Nikoubashman, Omid

AU - Stoffels, Gabriele

AU - Sheriff, Sulaiman

AU - Lohmann, Philipp

AU - Filss, Christian

AU - Galldiks, Norbert

AU - Kops, Elena Rota

AU - Jon Shah, N.

PY - 2018/4/1

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N2 - PET imaging of amino acid transport using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) May provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. Methods: In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in 18F-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Results: The average tumor volumes for 18F-FET uptake and increased Cho/NAA were 19 ± 20 cm3 (mean ± SD) and 22 ± 24 cm3, respectively, with an overlap of 40% ± 25% and separation of the centers of mass by 9 ± 8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion: 18F-FET uptake and increased Cho/NAA ratio are not always congruent and May represent different properties of glioma metabolism. The relationship to histologic tumor extent needs to be further analyzed.

AB - PET imaging of amino acid transport using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) May provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. Methods: In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in 18F-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Results: The average tumor volumes for 18F-FET uptake and increased Cho/NAA were 19 ± 20 cm3 (mean ± SD) and 22 ± 24 cm3, respectively, with an overlap of 40% ± 25% and separation of the centers of mass by 9 ± 8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion: 18F-FET uptake and increased Cho/NAA ratio are not always congruent and May represent different properties of glioma metabolism. The relationship to histologic tumor extent needs to be further analyzed.

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KW - Congruency

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KW - MRSI

KW - PET

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