Spatial population expansion promotes the evolution of cooperation in an experimental prisoner's dilemma

James Van Dyken, Melanie J I Müller, Keenan M L MacK, Michael M. Desai

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Cooperation is ubiquitous in nature, but explaining its existence remains a central interdisciplinary challenge [1-3]. Cooperation is most difficult to explain in the Prisoner's Dilemma game, where cooperators always lose in direct competition with defectors despite increasing mean fitness [1, 4, 5]. Here we demonstrate how spatial population expansion, a widespread natural phenomenon [6-11], promotes the evolution of cooperation. We engineer an experimental Prisoner's Dilemma game in the budding yeast Saccharomyces cerevisiae to show that, despite losing to defectors in nonexpanding conditions, cooperators increase in frequency in spatially expanding populations. Fluorescently labeled colonies show genetic demixing [8] of cooperators and defectors, followed by increase in cooperator frequency as cooperator sectors overtake neighboring defector sectors. Together with lattice-based spatial simulations, our results suggest that spatial population expansion drives the evolution of cooperation by (1) increasing positive genetic assortment at population frontiers and (2) selecting for phenotypes maximizing local deme productivity. Spatial expansion thus creates a selective force whereby cooperator-enriched demes overtake neighboring defector-enriched demes in a "survival of the fastest." We conclude that colony growth alone can promote cooperation and prevent defection in microbes. Our results extend to other species with spatially restricted dispersal undergoing range expansion, including pathogens, invasive species, and humans.

Original languageEnglish (US)
Pages (from-to)919-923
Number of pages5
JournalCurrent Biology
Volume23
Issue number10
DOIs
StatePublished - May 20 2013
Externally publishedYes

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prison inmates
Yeast
Population
Introduced Species
Saccharomycetales
Pathogens
engineers
invasive species
Saccharomyces cerevisiae
Productivity
yeasts
Phenotype
microorganisms
phenotype
Engineers
Survival
Prisoner Dilemma
pathogens
Growth

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Spatial population expansion promotes the evolution of cooperation in an experimental prisoner's dilemma. / Van Dyken, James; Müller, Melanie J I; MacK, Keenan M L; Desai, Michael M.

In: Current Biology, Vol. 23, No. 10, 20.05.2013, p. 919-923.

Research output: Contribution to journalArticle

Van Dyken, James ; Müller, Melanie J I ; MacK, Keenan M L ; Desai, Michael M. / Spatial population expansion promotes the evolution of cooperation in an experimental prisoner's dilemma. In: Current Biology. 2013 ; Vol. 23, No. 10. pp. 919-923.
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