This chapter examines the spatial patterns of gender gaps in the Global South. Data on gender gaps and inequality from various sources have been analyzed to capture the magnitude and scope of gender-based disparities and tracking their evolution. The World Economic Forum and the United Nations Development Program developed economic, political, educational, and health criteria for measuring national gender gaps. Spatially, South Asia and Central and South Africa reveal the highest levels of gender disparity. More in-depth analysis reveals regions with relatively higher gender inequalities are also more vulnerable to impacts of climate change. Thus, as a result of cultural and social norms, women and girls, particularly in the Global South, will be more exposed to the negative impacts of climate change. Based on the analyses of these indices, it is evident that there is a critical need to implement a more gender-sensitive approach toward mitigation and adaptation measures addressing the impacts of climate change at the regional scale.