Abstract
Neurosensory abnormalities have been implicated in the first stages of diabetic retinopathy. The activity of retinal ganglion cells in 24 Type 1 (insulin-dependent) diabetic patients with short disease duration without retinopathy on fluorescein angiography was investigated by using a pattern electroretinogram in response to sinusoidal gratings of different spatial frequencies (0.6, 1.0, 1.4, 2.2, 4.8 cycles/deg), counterphase modulated at 8 Hz. The pattern electroretinogram reflects, at least in part, the activity of subsets of generators (i. e., ganglion cells) which show spatial selectivity. Mean pattern electroretinogram amplitude was significantly reduced in patients at lower and intermediate, but not at higher spatial frequencies compared with 40 agematched control subjects. At 1.4 cycles/deg the pattern electroretinogram amplitude was significantly correlated (r=0.59) with age at onset (p=0.002) and duration of disease (p=0.002). Our results suggest that in Type 1 diabetic patients without retinopathy, there is an early sensory deficit of specific inner retina neurons which respond preferentially to gratings of medium and large size.
| Original language | English |
|---|---|
| Pages (from-to) | 726-730 |
| Number of pages | 5 |
| Journal | Diabetologia |
| Volume | 33 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 1990 |
| Externally published | Yes |
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Keywords
- diabetic retinopathy
- ganglion cells
- pattern electroretinogram
- Retinal function
- spatial frequency
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Spatial frequency-selective losses with pattern electroretinogram in Type 1 (insulin-dependent) diabetic patients without retinopathy. / Di Leo, M. A S; Falsini, B.; Caputo, S.; Ghirlanda, G.; Porciatti, Vittorio; Greco, A. V.
In: Diabetologia, Vol. 33, No. 12, 01.12.1990, p. 726-730.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spatial frequency-selective losses with pattern electroretinogram in Type 1 (insulin-dependent) diabetic patients without retinopathy
AU - Di Leo, M. A S
AU - Falsini, B.
AU - Caputo, S.
AU - Ghirlanda, G.
AU - Porciatti, Vittorio
AU - Greco, A. V.
PY - 1990/12/1
Y1 - 1990/12/1
N2 - Neurosensory abnormalities have been implicated in the first stages of diabetic retinopathy. The activity of retinal ganglion cells in 24 Type 1 (insulin-dependent) diabetic patients with short disease duration without retinopathy on fluorescein angiography was investigated by using a pattern electroretinogram in response to sinusoidal gratings of different spatial frequencies (0.6, 1.0, 1.4, 2.2, 4.8 cycles/deg), counterphase modulated at 8 Hz. The pattern electroretinogram reflects, at least in part, the activity of subsets of generators (i. e., ganglion cells) which show spatial selectivity. Mean pattern electroretinogram amplitude was significantly reduced in patients at lower and intermediate, but not at higher spatial frequencies compared with 40 agematched control subjects. At 1.4 cycles/deg the pattern electroretinogram amplitude was significantly correlated (r=0.59) with age at onset (p=0.002) and duration of disease (p=0.002). Our results suggest that in Type 1 diabetic patients without retinopathy, there is an early sensory deficit of specific inner retina neurons which respond preferentially to gratings of medium and large size.
AB - Neurosensory abnormalities have been implicated in the first stages of diabetic retinopathy. The activity of retinal ganglion cells in 24 Type 1 (insulin-dependent) diabetic patients with short disease duration without retinopathy on fluorescein angiography was investigated by using a pattern electroretinogram in response to sinusoidal gratings of different spatial frequencies (0.6, 1.0, 1.4, 2.2, 4.8 cycles/deg), counterphase modulated at 8 Hz. The pattern electroretinogram reflects, at least in part, the activity of subsets of generators (i. e., ganglion cells) which show spatial selectivity. Mean pattern electroretinogram amplitude was significantly reduced in patients at lower and intermediate, but not at higher spatial frequencies compared with 40 agematched control subjects. At 1.4 cycles/deg the pattern electroretinogram amplitude was significantly correlated (r=0.59) with age at onset (p=0.002) and duration of disease (p=0.002). Our results suggest that in Type 1 diabetic patients without retinopathy, there is an early sensory deficit of specific inner retina neurons which respond preferentially to gratings of medium and large size.
KW - diabetic retinopathy
KW - ganglion cells
KW - pattern electroretinogram
KW - Retinal function
KW - spatial frequency
UR - http://www.scopus.com/inward/record.url?scp=0025678894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025678894&partnerID=8YFLogxK
U2 - 10.1007/BF00400342
DO - 10.1007/BF00400342
M3 - Article
C2 - 2073985
AN - SCOPUS:0025678894
VL - 33
SP - 726
EP - 730
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 12
ER -