Spatial and temporal dynamics of a nonlocal viral infection model

Guangyu Zhao, Shigui Ruan

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Recent studies suggest that spatial heterogeneity plays an important role in the within-host infection of viruses such as HBV, HCV, and HIV. In this paper we propose a spatial model of viral dynamics on a bounded domain in which virus movement is described by a nonlocal (convolution) diffusion operator. The model is a spatial generalization of a basic ODE viral infection model that has been extensively studied in the literature. We investigate the principal eigenvalue of a perturbation of the nonlocal diffusion operator and show that the principal eigenvalue plays a key role similar to that of the basic reproduction number when it comes to determining the infection dynamics. Through analyzing the spectra of two matrix operators, it is shown that the model exhibits threshold dynamics. More precisely, if the principal eigenvalue is less than or equal to zero, then the infection-free steady state is asymptotically stable, while there is an infection steady state which is stable provided that the principal eigenvalue is greater than zero.

Original languageEnglish (US)
Pages (from-to)1954-1980
Number of pages27
JournalSIAM Journal on Applied Mathematics
Volume78
Issue number4
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Nonlocal diffusion operator
  • Principal eigenvalue
  • Spatial model
  • Stability
  • Viral infection

ASJC Scopus subject areas

  • Applied Mathematics

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