Spastic ataxia associated with human T-cell lymphotropic virus type II infection

William J. Harrington, William Sheremata, Brian Hjelle, Dipak K. Dube, Peggy Bradshaw, Steven K H Foung, Susan Snodgrass, Gary Toedter, Lisa Cabral, Bernard Poiesz

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Human T-cell lymphotropic virus type one (HTLV-1) is associated with tropical spastic paraparesis or HTLV-I-associated myelopathy. We report 2 women with a spastic ataxic illness similar to HTLV-I-associated myelopathy infected solely with HTLV-II. Identification of HTLV-II infection was made serologically, by polymerase chain reaction, and by viral culture (in 1 woman). One woman, treated with 200 mg of danazol orally, three times daily, had pronounced improvement in ambulation, nocturnal spasticity, and nighttime urinary frequency. It appears that infection with HTLV-II may cause an illness similar to HTLV-I-associated myelopathy, but distinguished by the presence of ataxia.

Original languageEnglish
Pages (from-to)411-414
Number of pages4
JournalAnnals of Neurology
Volume33
Issue number4
StatePublished - Apr 1 1993

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Human T-lymphotropic virus 2
Tropical Spastic Paraparesis
HTLV-II Infections
Virus Diseases
T-Lymphocytes
Danazol
Human T-lymphotropic virus 1
Muscle Spasticity
Ataxia
Walking
Viruses
Polymerase Chain Reaction
Spastic Ataxia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Harrington, W. J., Sheremata, W., Hjelle, B., Dube, D. K., Bradshaw, P., Foung, S. K. H., ... Poiesz, B. (1993). Spastic ataxia associated with human T-cell lymphotropic virus type II infection. Annals of Neurology, 33(4), 411-414.

Spastic ataxia associated with human T-cell lymphotropic virus type II infection. / Harrington, William J.; Sheremata, William; Hjelle, Brian; Dube, Dipak K.; Bradshaw, Peggy; Foung, Steven K H; Snodgrass, Susan; Toedter, Gary; Cabral, Lisa; Poiesz, Bernard.

In: Annals of Neurology, Vol. 33, No. 4, 01.04.1993, p. 411-414.

Research output: Contribution to journalArticle

Harrington, WJ, Sheremata, W, Hjelle, B, Dube, DK, Bradshaw, P, Foung, SKH, Snodgrass, S, Toedter, G, Cabral, L & Poiesz, B 1993, 'Spastic ataxia associated with human T-cell lymphotropic virus type II infection', Annals of Neurology, vol. 33, no. 4, pp. 411-414.
Harrington WJ, Sheremata W, Hjelle B, Dube DK, Bradshaw P, Foung SKH et al. Spastic ataxia associated with human T-cell lymphotropic virus type II infection. Annals of Neurology. 1993 Apr 1;33(4):411-414.
Harrington, William J. ; Sheremata, William ; Hjelle, Brian ; Dube, Dipak K. ; Bradshaw, Peggy ; Foung, Steven K H ; Snodgrass, Susan ; Toedter, Gary ; Cabral, Lisa ; Poiesz, Bernard. / Spastic ataxia associated with human T-cell lymphotropic virus type II infection. In: Annals of Neurology. 1993 ; Vol. 33, No. 4. pp. 411-414.
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