Sorting in the endosomal system in yeast and animal cells

Sandra K. Lemmon, Linton M. Traub

Research output: Contribution to journalReview articlepeer-review

176 Scopus citations


The endosomal system is a major membrane-sorting apparatus. New evidence reveals that novel coat proteins assist specific sorting steps and docking factors ensure the vectorial nature of trafficking in the endosomal compartment. There is also good evidence for ubiquitin regulating passage of certain proteins into multivesicular late endosomes, which mature by accumulating invaginated membrane. Lipids play a central role in this involution process, as do the class E vacuolar protein-sorting proteins.

Original languageEnglish (US)
Pages (from-to)457-466
Number of pages10
JournalCurrent Opinion in Cell Biology
Issue number4
StatePublished - Aug 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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