Sonication-based basic protocol for liposome synthesis

Roberto Mendez, Santanu Banerjee

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


Liposomes are spherical vesicles with a wide range of sizes from nano- to micrometer scale. For the past 7–8 decades, these vesicles have occupied the interest of a variety of scientists due to its physical, chemical, and mathematical properties and, to say the least, for its immense utility and potential as delivery vehicles for toxic and nontoxic excipients into biological tissues. Methods related to selection of reagents for creation of specific liposomes of certain properties are beyond the scope of this chapter, but here, we would outline a simplistic protocol to prepare and qualify an uniform batch of simple liposome with basic cargo. This chapter will attempt to provide the reader with a starting point for this immensely potent tool to build upon the right kind of liposome, appropriate for their studies.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages6
StatePublished - Jan 1 2017

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Drug delivery
  • Lipid
  • Lipid bilayer
  • Liposome
  • LUV
  • Phospholipids
  • Sonication
  • SUV
  • Vesicle

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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