Sonic hedgehog signaling is essential for hair development

B. St-Jacques, H. R. Dassule, I. Karavanova, V. A. Botchkarev, Jie Li, P. S. Danielian, J. A. McMahon, P. M. Lewis, Ralf Paus, A. P. McMahon

Research output: Contribution to journalArticle

534 Citations (Scopus)

Abstract

Background: The skin is responsible for forming a variety of epidermal structures that differ amongst vertebrates. In each case the specific structure (for example scale, feather or hair) arises from an epidermal placode as a result of epithelial-mesenchymal interactions with the underlying dermal mesenchyme. Expression of members of the Wnt, Hedgehog and bone morphogenetic protein families (Wnt10b, Sonic hedgehog (Shh) and Bmp2/Bmp4, respectively) in the epidermis correlates with the initiation of hair follicle formation. Further, their expression continues into either the epidermally derived hair matrix which forms the hair itself, or the dermal papilla which is responsible for induction of the hair matrix. To address the role of Shh in the hair follicle, we have examined Shh null mutant mice. Results: We found that follicle development in the Shh mutant embryo arrested after the initial epidermal-dermal interactions that lead to the formation of a dermal papilla anlage and ingrowth of the epidermis. Wnt10b, Bmp2 and Bmp4 continued to be expressed at this time, however. When grafted to nude mice (which lack T cells), Shh mutant skin gave rise to large abnormal follicles containing a small dermal papilla. Although these follicles showed high rates of proliferation and some differentiation of hair matrix cells into hair-shaft-like material, no hair was formed. Conclusions: Shh signaling is not required for initiating hair follicle development. Shh signaling is essential, however, for controlling ingrowth and morphogenesis of the hair follicle.

Original languageEnglish
Pages (from-to)1058-1068
Number of pages11
JournalCurrent Biology
Volume8
Issue number19
StatePublished - Sep 24 1998
Externally publishedYes

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Hedgehogs
Erinaceidae
Hair
hairs
Skin
Bone Morphogenetic Proteins
hair follicles
T-cells
Hair Follicle
epidermis (animal)
skin (animal)
Epidermis
mutants
bone morphogenetic proteins
Feathers
mice
Mesoderm
Morphogenesis
Nude Mice
feathers

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

St-Jacques, B., Dassule, H. R., Karavanova, I., Botchkarev, V. A., Li, J., Danielian, P. S., ... McMahon, A. P. (1998). Sonic hedgehog signaling is essential for hair development. Current Biology, 8(19), 1058-1068.

Sonic hedgehog signaling is essential for hair development. / St-Jacques, B.; Dassule, H. R.; Karavanova, I.; Botchkarev, V. A.; Li, Jie; Danielian, P. S.; McMahon, J. A.; Lewis, P. M.; Paus, Ralf; McMahon, A. P.

In: Current Biology, Vol. 8, No. 19, 24.09.1998, p. 1058-1068.

Research output: Contribution to journalArticle

St-Jacques, B, Dassule, HR, Karavanova, I, Botchkarev, VA, Li, J, Danielian, PS, McMahon, JA, Lewis, PM, Paus, R & McMahon, AP 1998, 'Sonic hedgehog signaling is essential for hair development', Current Biology, vol. 8, no. 19, pp. 1058-1068.
St-Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian PS et al. Sonic hedgehog signaling is essential for hair development. Current Biology. 1998 Sep 24;8(19):1058-1068.
St-Jacques, B. ; Dassule, H. R. ; Karavanova, I. ; Botchkarev, V. A. ; Li, Jie ; Danielian, P. S. ; McMahon, J. A. ; Lewis, P. M. ; Paus, Ralf ; McMahon, A. P. / Sonic hedgehog signaling is essential for hair development. In: Current Biology. 1998 ; Vol. 8, No. 19. pp. 1058-1068.
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