Sonic Hedgehog as a mediator of long-range signaling

John A. Goetz, Liza M. Suber, Xin Zeng, David J Robbins

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The ability of Hedgehog (Hh) proteins to exert their biological effects is regulated by a series of post-translational processes. These processes include an intramolecular cleavage, covalent addition of cholesterol and/or palmitate, and conversion into a multimeric freely diffusible form. The processing of Hh proteins affects their trafficking, potency, and ability to signal over many cell diameters. Accordingly, the loss of gene products required for these processes abrogates the Hh proteins' abilities to exert their effects, which can be long range, short range, or both. We review here recent evidence demonstrating that Hh proteins are directly responsible for their long-range biological effects. Additionally, we integrate both genetic and biochemical data to delineate a model illustrating how the unusual biochemistry of Hh family members may allow them to act as morphogens, signaling over both short and long distances.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalBioEssays
Volume24
Issue number2
DOIs
StatePublished - Mar 11 2002
Externally publishedYes

Fingerprint

Hedgehog Proteins
Erinaceidae
Aptitude
proteins
Biochemistry
Palmitates
palmitates
Molecular Biology
Genes
biochemistry
Cholesterol
cholesterol
Processing
genes

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Sonic Hedgehog as a mediator of long-range signaling. / Goetz, John A.; Suber, Liza M.; Zeng, Xin; Robbins, David J.

In: BioEssays, Vol. 24, No. 2, 11.03.2002, p. 157-165.

Research output: Contribution to journalArticle

Goetz, John A. ; Suber, Liza M. ; Zeng, Xin ; Robbins, David J. / Sonic Hedgehog as a mediator of long-range signaling. In: BioEssays. 2002 ; Vol. 24, No. 2. pp. 157-165.
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