Some metabolic relationships in young patients with ischemic heart disease

B. I. Joffe, W. A. Pocock, Ronald B Goldberg, N. J. Phillips, H. C. Seftel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The interrelationships between body weight, insulin secretion and serum lipids were studied in 40 young white patients (mean age 37 years) with established ischemic heart disease (IHD), living in Johannesburg. None was severely obese, hypertensive or overtly diabetic. In general, strong positive correlations were found between body weight and insulin concentrations and between insulin levels and fasting serum triglycerides. However, insulin levels were relatively low in 4 patients with marked hypertriglyceridemia (above 350 mg/dl). These data are consistent with the postulate that insulin promotes (hepatic) triglyceride synthesis, but when there is gross hypertriglyceridemia peripheral triglyceride clearance becomes defective. Insignificant correlations were observed between body weight and serum lipids and between cholesterol and other metabolic variables. We conclude that there is a sequential link between increasing body weight, insulin secretion and triglyceride levels in young patients with IHD, but that cholesterolemia is independent of this axis.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalAtherosclerosis
Volume24
Issue number3
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

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Myocardial Ischemia
Insulin
Triglycerides
Body Weight
Hypertriglyceridemia
Serum
Lipids
Fasting
Cholesterol
Liver

Keywords

  • Body weight
  • Cholesterol
  • Insulin
  • Ischemic heart disease
  • Triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Some metabolic relationships in young patients with ischemic heart disease. / Joffe, B. I.; Pocock, W. A.; Goldberg, Ronald B; Phillips, N. J.; Seftel, H. C.

In: Atherosclerosis, Vol. 24, No. 3, 01.01.1976, p. 581-586.

Research output: Contribution to journalArticle

Joffe, B. I. ; Pocock, W. A. ; Goldberg, Ronald B ; Phillips, N. J. ; Seftel, H. C. / Some metabolic relationships in young patients with ischemic heart disease. In: Atherosclerosis. 1976 ; Vol. 24, No. 3. pp. 581-586.
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