Some factors influencing the proliferation and differentiation of myelin-forming cells

R. P. Bunge, M. Bartlett Bunge, M. Cochran

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Fundamental questions arising from study of the multiple sclerosis lesion are: why the myelin-forming oligodendrocyte is adversely affected; and what factors might induce the proliferation and differentiation of replacement oligodendrocytes. This paper discusses factors that influence the number and differentiative capacity of myelin-forming cells both in the central nervous system and the peripheral nervous system. New experiments utilizing cultures of fetal rat sensory and autonomic ganglia are also herein reported. It has been found that in cultures free of fibroblasts, normal Schwann cell proliferation and ensheathment of axons require contact with a collagen substrate and may be facilitated by a medium containing chick embryo extract. This demonstration of a connective tissue requirement for normal Schwann cell function raises the question of whether additional factors are necessary for normal oligodendrocyte activity.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
Issue number9 II
StatePublished - 1978

ASJC Scopus subject areas

  • Clinical Neurology


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