Somatostatin promotes accumulation of phospholipids in regenerating liver tissue of rats

Cedomila Milin, Biserka Radosevic-Stasic, Madena Kirigin, Visnja Hinic, Daniel Rukavina, Per Olof Berggren, Saud Efendic

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Effects of somatostatin (SOM) on tissue contents of proteins, total lipids and phospholipids were investigated in regenerating and intact liver tissue of Y-59 rats. Whereas SOM inhibited protein accumulation in regenerating liver, the hormone evoked and increase in total lipids, and specially in phosphatidylcholine, phosphatidylethnolamine, phosphatidylserine (PS) and phosphatidylinositol (PI). Since the same effects were not seen when intact liver was analyzed, it is assumed that SOM acts primarily on tissue stimulated to rapid growth. The increase of PS+PI fractions indicates a specific effect of SOM on the metabolism of phosphatidylinositides. Such an effect might result from the interference of the hormone with the action of growth factors that accelerate phosphatidylinositol breakdown.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBioscience reports
Volume11
Issue number1
DOIs
StatePublished - Feb 1991

Keywords

  • lipid
  • liver
  • phospholipid
  • regenerating liver
  • somatostatin

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)

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    Milin, C., Radosevic-Stasic, B., Kirigin, M., Hinic, V., Rukavina, D., Berggren, P. O., & Efendic, S. (1991). Somatostatin promotes accumulation of phospholipids in regenerating liver tissue of rats. Bioscience reports, 11(1), 1-6. https://doi.org/10.1007/BF01118598