Somatostatin can locally inhibit proliferation and differentiation of cartilage and bone precursor cells

Roy E. Weiss, A. H. Reddi, M. E. Nimni

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The influence of somatostatin on discrete stages of collagenous-matrix-induced endochondral bone formation has been investigated. Local injection of somatostatin, i.e., without any measurable systemic effect, resulted in a 75% reduction of cell proliferation as measured by [3H]thymidine incorporation and ornithine decarboxylase activities. The minimum effective inhibitory dose of somatostatin was 0.25 μg/day. Twice daily local injections of the hormone during cartilage formation also resulted in an inhibition, but this was shown to be due to impaired cell proliferation rather than to a direct effect of somatostatin on differentiation. Injection of somatostatin into developing bone tissue after the cartilage stage impaired osteogenesis, assessed by45Ca incorporation and alkaline phosphatase activity. Concurrent injections of insulin and somatostatin obliterated the inhibitory effect of the latter on cell proliferation. Somatostatin can locally regulate the proliferation and differentiation of chondroprogenitor and osteoprogenitor cells in vivo and may directly contribute to the regulation of bone growth by its ability to counteract the stimulatory effect of insulin.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalCalcified Tissue International
Volume33
Issue number1
DOIs
StatePublished - Dec 1 1981
Externally publishedYes

Keywords

  • Bone induction
  • Chondrogenesis
  • Insulin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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