Somatostatin and its analog enhance the formation of human leukocyte migration inhibiting factor: Further evidence for immunomodulatory action of somatostatin

Marek Pawlikowski, Piotr Zelazowski, Henryk Stepien, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The effect of somatostatin-14 (SST) and somatostatin analog D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-NH2 (RC-102) on migration inhibition of human leukocytes induced by cardiac antigen or phytohemagglutinin (PHA) was investigated. Both SST and RC-102 augmented the migration inhibition, thus indicating the enhanced formation or action of the leukocyte migration inhibiting factor (LMIF). This finding provides additional evidence for the immunomodulatory action of somatostatin.

Original languageEnglish (US)
Pages (from-to)951-952
Number of pages2
JournalPeptides
Volume8
Issue number5
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Keywords

  • Immunomodulatory action
  • Leukocyte migration inhibition factor (LMIF)
  • Somatostatin
  • Somatostatin analog

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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