Three analogs of somatostatin, [D-Cys14] -, [Ala2, D-Cys14] - and [D-Trp8, D-Cys14] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo, but had less effect on insulin secretion in vivo. These analogs, particularly [D-Trp8, D-Cys14] - somatostatin, could possibly be useful for the treatment of diabetes mellitus.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochemical and biophysical research communications|
|State||Published - Jan 24 1977|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology