Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release

Chester Meyers, Akira Arimura, Ariel Gordin, R. Fernandez-Durango, David H. Coy, Andrew V Schally, Jacques Drouin, Louise Ferland, Michele Beaulieu, Fernand Labrie

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Three analogs of somatostatin, [D-Cys14] -, [Ala2, D-Cys14] - and [D-Trp8, D-Cys14] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo, but had less effect on insulin secretion in vivo. These analogs, particularly [D-Trp8, D-Cys14] - somatostatin, could possibly be useful for the treatment of diabetes mellitus.

Original languageEnglish
Pages (from-to)630-636
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume74
Issue number2
DOIs
StatePublished - Jan 24 1977
Externally publishedYes

Fingerprint

Somatostatin
Glucagon
Growth Hormone
Insulin
Medical problems
Diabetes Mellitus
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release. / Meyers, Chester; Arimura, Akira; Gordin, Ariel; Fernandez-Durango, R.; Coy, David H.; Schally, Andrew V; Drouin, Jacques; Ferland, Louise; Beaulieu, Michele; Labrie, Fernand.

In: Biochemical and Biophysical Research Communications, Vol. 74, No. 2, 24.01.1977, p. 630-636.

Research output: Contribution to journalArticle

Meyers, C, Arimura, A, Gordin, A, Fernandez-Durango, R, Coy, DH, Schally, AV, Drouin, J, Ferland, L, Beaulieu, M & Labrie, F 1977, 'Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release', Biochemical and Biophysical Research Communications, vol. 74, no. 2, pp. 630-636. https://doi.org/10.1016/0006-291X(77)90349-7
Meyers, Chester ; Arimura, Akira ; Gordin, Ariel ; Fernandez-Durango, R. ; Coy, David H. ; Schally, Andrew V ; Drouin, Jacques ; Ferland, Louise ; Beaulieu, Michele ; Labrie, Fernand. / Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release. In: Biochemical and Biophysical Research Communications. 1977 ; Vol. 74, No. 2. pp. 630-636.
@article{68824c5755a445ae90fff43b085c6170,
title = "Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release",
abstract = "Three analogs of somatostatin, [D-Cys14] -, [Ala2, D-Cys14] - and [D-Trp8, D-Cys14] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo, but had less effect on insulin secretion in vivo. These analogs, particularly [D-Trp8, D-Cys14] - somatostatin, could possibly be useful for the treatment of diabetes mellitus.",
author = "Chester Meyers and Akira Arimura and Ariel Gordin and R. Fernandez-Durango and Coy, {David H.} and Schally, {Andrew V} and Jacques Drouin and Louise Ferland and Michele Beaulieu and Fernand Labrie",
year = "1977",
month = "1",
day = "24",
doi = "10.1016/0006-291X(77)90349-7",
language = "English",
volume = "74",
pages = "630--636",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release

AU - Meyers, Chester

AU - Arimura, Akira

AU - Gordin, Ariel

AU - Fernandez-Durango, R.

AU - Coy, David H.

AU - Schally, Andrew V

AU - Drouin, Jacques

AU - Ferland, Louise

AU - Beaulieu, Michele

AU - Labrie, Fernand

PY - 1977/1/24

Y1 - 1977/1/24

N2 - Three analogs of somatostatin, [D-Cys14] -, [Ala2, D-Cys14] - and [D-Trp8, D-Cys14] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo, but had less effect on insulin secretion in vivo. These analogs, particularly [D-Trp8, D-Cys14] - somatostatin, could possibly be useful for the treatment of diabetes mellitus.

AB - Three analogs of somatostatin, [D-Cys14] -, [Ala2, D-Cys14] - and [D-Trp8, D-Cys14] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo, but had less effect on insulin secretion in vivo. These analogs, particularly [D-Trp8, D-Cys14] - somatostatin, could possibly be useful for the treatment of diabetes mellitus.

UR - http://www.scopus.com/inward/record.url?scp=0017614038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017614038&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(77)90349-7

DO - 10.1016/0006-291X(77)90349-7

M3 - Article

VL - 74

SP - 630

EP - 636

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -