TY - JOUR
T1 - Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release
AU - Meyers, Chester
AU - Arimura, Akira
AU - Gordin, Ariel
AU - Fernandez-Durango, R.
AU - Coy, David H.
AU - Schally, Andrew V.
AU - Drouin, Jacques
AU - Ferland, Louise
AU - Beaulieu, Michele
AU - Labrie, Fernand
PY - 1977/1/24
Y1 - 1977/1/24
N2 - Three analogs of somatostatin, [D-Cys14] -, [Ala2, D-Cys14] - and [D-Trp8, D-Cys14] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo, but had less effect on insulin secretion in vivo. These analogs, particularly [D-Trp8, D-Cys14] - somatostatin, could possibly be useful for the treatment of diabetes mellitus.
AB - Three analogs of somatostatin, [D-Cys14] -, [Ala2, D-Cys14] - and [D-Trp8, D-Cys14] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo, but had less effect on insulin secretion in vivo. These analogs, particularly [D-Trp8, D-Cys14] - somatostatin, could possibly be useful for the treatment of diabetes mellitus.
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U2 - 10.1016/0006-291X(77)90349-7
DO - 10.1016/0006-291X(77)90349-7
M3 - Article
C2 - 836315
AN - SCOPUS:0017614038
VL - 74
SP - 630
EP - 636
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -
