Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release

Chester Meyers; Akira Arimura; Ariel Gordin; R. Fernandez-Durango; David H. Coy; Andrew V. Schally; Jacques Drouin; Louise Ferland; Michele Beaulieu; Fernand Labrie

doi:10.1016/0006-291X(77)90349-7

Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release

Chester Meyers, Akira Arimura, Ariel Gordin, R. Fernandez-Durango, David H. Coy, Andrew V. Schally, Jacques Drouin, Louise Ferland, Michele Beaulieu, Fernand Labrie

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Three analogs of somatostatin, [D-Cys¹⁴] -, [Ala², D-Cys¹⁴] - and [D-Trp⁸, D-Cys¹⁴] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo, but had less effect on insulin secretion in vivo. These analogs, particularly [D-Trp⁸, D-Cys¹⁴] - somatostatin, could possibly be useful for the treatment of diabetes mellitus.

Original language	English (US)
Pages (from-to)	630-636
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	74
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(77)90349-7
State	Published - Jan 24 1977
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release. / Meyers, Chester; Arimura, Akira; Gordin, Ariel; Fernandez-Durango, R.; Coy, David H.; Schally, Andrew V.; Drouin, Jacques; Ferland, Louise; Beaulieu, Michele; Labrie, Fernand.

In: Biochemical and biophysical research communications, Vol. 74, No. 2, 24.01.1977, p. 630-636.

Research output: Contribution to journal › Article › peer-review

Meyers, Chester ; Arimura, Akira ; Gordin, Ariel ; Fernandez-Durango, R. ; Coy, David H. ; Schally, Andrew V. ; Drouin, Jacques ; Ferland, Louise ; Beaulieu, Michele ; Labrie, Fernand. / Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release. In: Biochemical and biophysical research communications. 1977 ; Vol. 74, No. 2. pp. 630-636.

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