Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release

Chester Meyers, Akira Arimura, Ariel Gordin, R. Fernandez-Durango, David H. Coy, Andrew V. Schally, Jacques Drouin, Louise Ferland, Michele Beaulieu, Fernand Labrie

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Three analogs of somatostatin, [D-Cys14] -, [Ala2, D-Cys14] - and [D-Trp8, D-Cys14] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo, but had less effect on insulin secretion in vivo. These analogs, particularly [D-Trp8, D-Cys14] - somatostatin, could possibly be useful for the treatment of diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)630-636
Number of pages7
JournalBiochemical and biophysical research communications
Volume74
Issue number2
DOIs
StatePublished - Jan 24 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release'. Together they form a unique fingerprint.

Cite this