Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice

Jacek Pinski, Andrew V Schally, Gabor Halmos, Karoly Szepeshazi, Kate Groot

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We investigated the effects of the potent somatostatin analog RC-160 on the growth of human osteosarcoma cell lines SKE-ES-1 and MNNG/HOS, transplanted into nude mice or cultured in vitro. Growth of SK-ES-1 and MNNG/HOS tumors in nude mice was significantly inhibited after 4 weeks of treatment with daily s.c. injections of 100 μg RC-160, as measured by a reduction in tumor volume and weight. Histologically, the number of mitotic cells was decreased in the groups treated with RC-160. In mice bearing either tumor model, administration of RC-160 significantly decreased serum growth hormone and insulin-like growth factor I (IGF-I) levels. Specific high-affinity receptors for somatostatin and epidermal growth factor were found on membranes of MNNG/HOS tumors but not on SK-ES-1 tumors. Receptor analyses also demonstrated high-affinity binding sites for IGF-I on membranes of both tumors. In cell cultures, the proliferation rate of MNNG/HOS cells, but not of SK-ES-1, was significantly suppressed by RC-160. Our findings demonstrate that RC-160 can significantly inhibit the growth of SK-ES-1 and MNNG/HOS osteosarcomas in mice.

Original languageEnglish
Pages (from-to)870-874
Number of pages5
JournalInternational Journal of Cancer
Volume65
Issue number6
DOIs
StatePublished - Mar 15 1996
Externally publishedYes

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Methylnitronitrosoguanidine
Osteosarcoma
Somatostatin
Nude Mice
Growth
Neoplasms
Tumor Burden
Insulin-Like Growth Factor I
Membranes
Growth Hormone
vapreotide
Cell Culture Techniques
Cell Count
Binding Sites
Cell Proliferation
Cell Line
Injections
Serum

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice. / Pinski, Jacek; Schally, Andrew V; Halmos, Gabor; Szepeshazi, Karoly; Groot, Kate.

In: International Journal of Cancer, Vol. 65, No. 6, 15.03.1996, p. 870-874.

Research output: Contribution to journalArticle

Pinski, Jacek ; Schally, Andrew V ; Halmos, Gabor ; Szepeshazi, Karoly ; Groot, Kate. / Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice. In: International Journal of Cancer. 1996 ; Vol. 65, No. 6. pp. 870-874.
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