Abstract
Growth hormone release inhibiting hormone (somatostatin), a hypothalamic peptide that inhibits the release of growth hormone and also the secretion of insulin, glucagon, and gastrin, was found in the rat stomach and pancreas in a concentration similar to that in the hypothalamus, as measured by radioimmunoassay. Somatostatin was also found in the duodenum and jejunum, but in a smaller concentration. Gel filtration of the extracts of the pancreas and stomach on Sephadex G 25 yielded two immunoreactive peaks, one corresponding in each case to the somatostatin tetradecapeptide. The hormone was not detected in other viscera or the ovaries. The results imply that somatostatin may be synthesized in the pancreas and the stomach in addition to the brain, and may be involved in local regulatory mechanisms for pancreatic and gastric secretion as well as secretion of growth hormone.
| Original language | English |
|---|---|
| Pages (from-to) | 1007-1009 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 189 |
| Issue number | 4207 |
| State | Published - Dec 1 1975 |
| Externally published | Yes |
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Cite this
Somatostatin : abundance of immunoreactive hormone in rat stomach and pancreas. / Arimura, A.; Sato, H.; Dupont, A.; Nishi, N.; Schally, Andrew V.
In: Science, Vol. 189, No. 4207, 01.12.1975, p. 1007-1009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Somatostatin
T2 - abundance of immunoreactive hormone in rat stomach and pancreas
AU - Arimura, A.
AU - Sato, H.
AU - Dupont, A.
AU - Nishi, N.
AU - Schally, Andrew V
PY - 1975/12/1
Y1 - 1975/12/1
N2 - Growth hormone release inhibiting hormone (somatostatin), a hypothalamic peptide that inhibits the release of growth hormone and also the secretion of insulin, glucagon, and gastrin, was found in the rat stomach and pancreas in a concentration similar to that in the hypothalamus, as measured by radioimmunoassay. Somatostatin was also found in the duodenum and jejunum, but in a smaller concentration. Gel filtration of the extracts of the pancreas and stomach on Sephadex G 25 yielded two immunoreactive peaks, one corresponding in each case to the somatostatin tetradecapeptide. The hormone was not detected in other viscera or the ovaries. The results imply that somatostatin may be synthesized in the pancreas and the stomach in addition to the brain, and may be involved in local regulatory mechanisms for pancreatic and gastric secretion as well as secretion of growth hormone.
AB - Growth hormone release inhibiting hormone (somatostatin), a hypothalamic peptide that inhibits the release of growth hormone and also the secretion of insulin, glucagon, and gastrin, was found in the rat stomach and pancreas in a concentration similar to that in the hypothalamus, as measured by radioimmunoassay. Somatostatin was also found in the duodenum and jejunum, but in a smaller concentration. Gel filtration of the extracts of the pancreas and stomach on Sephadex G 25 yielded two immunoreactive peaks, one corresponding in each case to the somatostatin tetradecapeptide. The hormone was not detected in other viscera or the ovaries. The results imply that somatostatin may be synthesized in the pancreas and the stomach in addition to the brain, and may be involved in local regulatory mechanisms for pancreatic and gastric secretion as well as secretion of growth hormone.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016810983&partnerID=8YFLogxK
M3 - Article
C2 - 56779
AN - SCOPUS:0016810983
VL - 189
SP - 1007
EP - 1009
JO - Science
JF - Science
SN - 0036-8075
IS - 4207
ER -