Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials

Neil P. Desai, Jeffrey A. Hubbell

Research output: Contribution to journalArticlepeer-review

240 Scopus citations

Abstract

A simple solution technique was used to incorporate polyethylene oxide (PEO, of 5000,10 000,18 500, and 100 000 g/mol) and other water-soluble polymers such as polyvinylpyrrolidone and polyethyl oxazoline into the surfaces of commonly used biomedical polymers such as polyethylene terephthalate, a Polyurethane (Pellethane® 2363-80AE), and polymethylmethacrylate. The presence of the water-soluble polymers on these surfaces was verified by using contact angle analysis and ESCA. Protein adsorption studies, fibroblast adhesion assays, and whole blood perfusions over these polymers showed that the surface modified with PEO 18 500 was the most effective in reducing all the tested biological interactions. It was concluded that PEO 18 500 had a chain length that was optimal, using this technique for surface incorporation, to reduce protein adsorption and hence prevent protein-mediated biological interactions.

Original languageEnglish (US)
Pages (from-to)144-153
Number of pages10
JournalBiomaterials
Volume12
Issue number2
DOIs
StatePublished - Mar 1991

Keywords

  • Blood-polymer interactions
  • polyethylene oxide
  • surface treatment

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials'. Together they form a unique fingerprint.

Cite this