Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection

Chris T. Longenecker, Ying Jiang, Carl Edward Orringer, Robert C. Gilkeson, Sara Debanne, Nicholas T. Funderburg, Michael M. Lederman, Norma Storer, Danielle E. Labbato, Grace A. McComsey

Research output: Contribution to journalArticle

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Abstract

Objective: To use multimodality imaging to explore the relationship of biomarkers of inflammation, T-cell activation and monocyte activation with coronary calcification and subclinical vascular disease in a population of HIV-infected patients on antiretroviral therapy (ART). Design: Cross-sectional. Methods: A panel of soluble and cellular biomarkers of inflammation and immune activation was measured in 147 HIV-infected adults on ART with HIV RNA less than 1000 copies/ml and low-density lipoprotein cholesterol (LDL-C) 130 mg/dl or less. We examined the relationship of biomarkers to coronary calcium (CAC) score and multiple ultrasound measures of subclinical vascular disease. Results: Overall, median (interquartile range, IQR) age was 46 (40-53) years; threequarters of participants were male and two-thirds African-American. Median 10-year Framingham risk score was 6%. Participants with CAC more than 0 were older, less likely to be African-American and had higher current and lower nadir CD4\+ T-cell counts. Most biomarkers were similar between those with and without CAC; however, soluble CD14 was independently associated with CAC after adjustment for traditional risk factors. Among those with a CAC score of zero, T-cell activation and systemic inflammation correlated with carotid intima-media thickness and brachial hyperemic velocity, respectively. Compared with normal participants and those with CAC only, participants with increasing degrees of subclinical vascular disease had higher levels of sCD14, hs-CRP and fibrinogen (all P0.05). Conclusion: Soluble CD14 is independently associated with coronary artery calcification, and, among those with detectable calcium, predicts the extent of subclinical disease in other vascular beds. Future studies should investigate the utility of multimodality imaging to characterize vascular disease phenotypes in this population.

Original languageEnglish (US)
Pages (from-to)969-977
Number of pages9
JournalAIDS
Volume28
Issue number7
DOIs
StatePublished - Apr 24 2014
Externally publishedYes

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Vascular Diseases
HIV Infections
Calcium
Biomarkers
HIV
Inflammation
T-Lymphocytes
African Americans
Carotid Intima-Media Thickness
CD4 Lymphocyte Count
LDL Cholesterol
Fibrinogen
Population
Blood Vessels
Monocytes
Coronary Vessels
Arm
RNA
Phenotype
Therapeutics

Keywords

  • carotid intima-media thickness
  • coronary artery calcium
  • endothelial function
  • HIV
  • inflammation
  • microbial translocation
  • soluble CD14

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection. / Longenecker, Chris T.; Jiang, Ying; Orringer, Carl Edward; Gilkeson, Robert C.; Debanne, Sara; Funderburg, Nicholas T.; Lederman, Michael M.; Storer, Norma; Labbato, Danielle E.; McComsey, Grace A.

In: AIDS, Vol. 28, No. 7, 24.04.2014, p. 969-977.

Research output: Contribution to journalArticle

Longenecker, CT, Jiang, Y, Orringer, CE, Gilkeson, RC, Debanne, S, Funderburg, NT, Lederman, MM, Storer, N, Labbato, DE & McComsey, GA 2014, 'Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection', AIDS, vol. 28, no. 7, pp. 969-977. https://doi.org/10.1097/QAD.0000000000000158
Longenecker, Chris T. ; Jiang, Ying ; Orringer, Carl Edward ; Gilkeson, Robert C. ; Debanne, Sara ; Funderburg, Nicholas T. ; Lederman, Michael M. ; Storer, Norma ; Labbato, Danielle E. ; McComsey, Grace A. / Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection. In: AIDS. 2014 ; Vol. 28, No. 7. pp. 969-977.
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abstract = "Objective: To use multimodality imaging to explore the relationship of biomarkers of inflammation, T-cell activation and monocyte activation with coronary calcification and subclinical vascular disease in a population of HIV-infected patients on antiretroviral therapy (ART). Design: Cross-sectional. Methods: A panel of soluble and cellular biomarkers of inflammation and immune activation was measured in 147 HIV-infected adults on ART with HIV RNA less than 1000 copies/ml and low-density lipoprotein cholesterol (LDL-C) 130 mg/dl or less. We examined the relationship of biomarkers to coronary calcium (CAC) score and multiple ultrasound measures of subclinical vascular disease. Results: Overall, median (interquartile range, IQR) age was 46 (40-53) years; threequarters of participants were male and two-thirds African-American. Median 10-year Framingham risk score was 6{\%}. Participants with CAC more than 0 were older, less likely to be African-American and had higher current and lower nadir CD4\+ T-cell counts. Most biomarkers were similar between those with and without CAC; however, soluble CD14 was independently associated with CAC after adjustment for traditional risk factors. Among those with a CAC score of zero, T-cell activation and systemic inflammation correlated with carotid intima-media thickness and brachial hyperemic velocity, respectively. Compared with normal participants and those with CAC only, participants with increasing degrees of subclinical vascular disease had higher levels of sCD14, hs-CRP and fibrinogen (all P0.05). Conclusion: Soluble CD14 is independently associated with coronary artery calcification, and, among those with detectable calcium, predicts the extent of subclinical disease in other vascular beds. Future studies should investigate the utility of multimodality imaging to characterize vascular disease phenotypes in this population.",
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T1 - Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection

AU - Longenecker, Chris T.

AU - Jiang, Ying

AU - Orringer, Carl Edward

AU - Gilkeson, Robert C.

AU - Debanne, Sara

AU - Funderburg, Nicholas T.

AU - Lederman, Michael M.

AU - Storer, Norma

AU - Labbato, Danielle E.

AU - McComsey, Grace A.

PY - 2014/4/24

Y1 - 2014/4/24

N2 - Objective: To use multimodality imaging to explore the relationship of biomarkers of inflammation, T-cell activation and monocyte activation with coronary calcification and subclinical vascular disease in a population of HIV-infected patients on antiretroviral therapy (ART). Design: Cross-sectional. Methods: A panel of soluble and cellular biomarkers of inflammation and immune activation was measured in 147 HIV-infected adults on ART with HIV RNA less than 1000 copies/ml and low-density lipoprotein cholesterol (LDL-C) 130 mg/dl or less. We examined the relationship of biomarkers to coronary calcium (CAC) score and multiple ultrasound measures of subclinical vascular disease. Results: Overall, median (interquartile range, IQR) age was 46 (40-53) years; threequarters of participants were male and two-thirds African-American. Median 10-year Framingham risk score was 6%. Participants with CAC more than 0 were older, less likely to be African-American and had higher current and lower nadir CD4\+ T-cell counts. Most biomarkers were similar between those with and without CAC; however, soluble CD14 was independently associated with CAC after adjustment for traditional risk factors. Among those with a CAC score of zero, T-cell activation and systemic inflammation correlated with carotid intima-media thickness and brachial hyperemic velocity, respectively. Compared with normal participants and those with CAC only, participants with increasing degrees of subclinical vascular disease had higher levels of sCD14, hs-CRP and fibrinogen (all P0.05). Conclusion: Soluble CD14 is independently associated with coronary artery calcification, and, among those with detectable calcium, predicts the extent of subclinical disease in other vascular beds. Future studies should investigate the utility of multimodality imaging to characterize vascular disease phenotypes in this population.

AB - Objective: To use multimodality imaging to explore the relationship of biomarkers of inflammation, T-cell activation and monocyte activation with coronary calcification and subclinical vascular disease in a population of HIV-infected patients on antiretroviral therapy (ART). Design: Cross-sectional. Methods: A panel of soluble and cellular biomarkers of inflammation and immune activation was measured in 147 HIV-infected adults on ART with HIV RNA less than 1000 copies/ml and low-density lipoprotein cholesterol (LDL-C) 130 mg/dl or less. We examined the relationship of biomarkers to coronary calcium (CAC) score and multiple ultrasound measures of subclinical vascular disease. Results: Overall, median (interquartile range, IQR) age was 46 (40-53) years; threequarters of participants were male and two-thirds African-American. Median 10-year Framingham risk score was 6%. Participants with CAC more than 0 were older, less likely to be African-American and had higher current and lower nadir CD4\+ T-cell counts. Most biomarkers were similar between those with and without CAC; however, soluble CD14 was independently associated with CAC after adjustment for traditional risk factors. Among those with a CAC score of zero, T-cell activation and systemic inflammation correlated with carotid intima-media thickness and brachial hyperemic velocity, respectively. Compared with normal participants and those with CAC only, participants with increasing degrees of subclinical vascular disease had higher levels of sCD14, hs-CRP and fibrinogen (all P0.05). Conclusion: Soluble CD14 is independently associated with coronary artery calcification, and, among those with detectable calcium, predicts the extent of subclinical disease in other vascular beds. Future studies should investigate the utility of multimodality imaging to characterize vascular disease phenotypes in this population.

KW - carotid intima-media thickness

KW - coronary artery calcium

KW - endothelial function

KW - HIV

KW - inflammation

KW - microbial translocation

KW - soluble CD14

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