Soluble and membrane-associated interleukin 2 receptor-α expression in rhesus monkeys infected with simian immunodeficiency virus

D. J. Ringler, D. G. Walsh, L. V. Chalifoux, J. J. MacKey, M. D. Daniel, Ronald Charles Desrosiers, N. W. King, W. W. Hancock

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

More than 80% of rhesus monkeys infected with simian immunodeficiency virus (SIV) were found to have elevated levels of soluble interleukin-2 receptor (IL-2R) in their serum during the course of infection. All long-term survivors had stably elevated levels of soluble IL-2R. The highest levels of soluble IL-2R correlated with the expression of IL-2R on tissue macrophages. Although IL-2R expression was induced on alveolar macrophages by infection with SIV in vitro, expression of IL-2R on tissue macrophages in vivo was not associated with concurrent SIV protein expression in the same cells. Moreover, in animals with high soluble IL-2R levels, there was an inverse relationship between the numbers of cells expressing IL-2R and cells expressing viral protein. The results suggest that the induction of IL-2R may be an indirect or secondary effect of SIV infection. Changes in expression of macrophage-elaborated factors, such as that of IL-2R described in this report, may play a crucial role in some of the pathologic features of acquired immunodeficiency syndrome.

Original languageEnglish (US)
Pages (from-to)435-443
Number of pages9
JournalLaboratory Investigation
Volume62
Issue number4
StatePublished - 1990
Externally publishedYes

Fingerprint

Simian Immunodeficiency Virus
Interleukin-2 Receptors
Macaca mulatta
Membranes
Macrophages
Alveolar Macrophages
Viral Proteins
Virus Diseases
Infection
Survivors
Acquired Immunodeficiency Syndrome
Cell Count

Keywords

  • AIDS
  • IL-2R
  • macrophages
  • SIV

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ringler, D. J., Walsh, D. G., Chalifoux, L. V., MacKey, J. J., Daniel, M. D., Desrosiers, R. C., ... Hancock, W. W. (1990). Soluble and membrane-associated interleukin 2 receptor-α expression in rhesus monkeys infected with simian immunodeficiency virus. Laboratory Investigation, 62(4), 435-443.

Soluble and membrane-associated interleukin 2 receptor-α expression in rhesus monkeys infected with simian immunodeficiency virus. / Ringler, D. J.; Walsh, D. G.; Chalifoux, L. V.; MacKey, J. J.; Daniel, M. D.; Desrosiers, Ronald Charles; King, N. W.; Hancock, W. W.

In: Laboratory Investigation, Vol. 62, No. 4, 1990, p. 435-443.

Research output: Contribution to journalArticle

Ringler, DJ, Walsh, DG, Chalifoux, LV, MacKey, JJ, Daniel, MD, Desrosiers, RC, King, NW & Hancock, WW 1990, 'Soluble and membrane-associated interleukin 2 receptor-α expression in rhesus monkeys infected with simian immunodeficiency virus', Laboratory Investigation, vol. 62, no. 4, pp. 435-443.
Ringler, D. J. ; Walsh, D. G. ; Chalifoux, L. V. ; MacKey, J. J. ; Daniel, M. D. ; Desrosiers, Ronald Charles ; King, N. W. ; Hancock, W. W. / Soluble and membrane-associated interleukin 2 receptor-α expression in rhesus monkeys infected with simian immunodeficiency virus. In: Laboratory Investigation. 1990 ; Vol. 62, No. 4. pp. 435-443.
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