Soluble adhesion molecules as surrogate markers of endothelial activation/injury in patients with severe uncontrolled hypertension (HT)

R. A. Preston, Marlies Ledford, N. M. Baltodano, A. Alonso, B. J. Materson

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Abstract

Purpose: Elevated levels of soluble vascular cell adhesion molecule-1 (sVCAM) and soluble intercellular adhesion molecule- 1 (sICAM) have been reported in HT and have been used as surrogate markers of vascular injury in therapeutic drug trials. However, the effects of extreme HT on these soluble markers and their precision as indicators of hypertensive vascular injury are not entirely established. Methods: Comparison of sVCAM, and sICAM among 3 groups: Untreated severe HT (SHT) with diastolic blood pressure (DBP)≥120 mm Hg (n=24), mild HT (MHT) with DBP<100 mm Hg (n=19), normotensive subjects (NT; n=15). Results: [Mean (SD)]: sVCAM (p=.0001) and sICAM (p=.006) were greater in SHT and MHT than NT but did not differ between SHT and MHT. SHT MHT NT sVCAM 635 (237) 690 (215) 389 (72) sICAM 234 (88) 262 (74) 179 (45) Conclusion: Concentrations of soluble adhesion molecules may depend more strongly upon other factors in the hypertensive micro-environment than the absolute level of blood pressure.

Original languageEnglish (US)
Pages (from-to)P74
JournalClinical Pharmacology and Therapeutics
Volume69
Issue number2
StatePublished - Dec 1 2001

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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