Soluble adenylyl cyclase in health and disease

Andreas Schmid, Dimirela Meili, Matthias A Salathe

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The second messenger cAMP is integral for many physiological processes. Soluble adenylyl cyclase (sAC) was recently identified as a widely expressed intracellular source of cAMP in mammalian cells. sAC is evolutionary, structurally, and biochemically distinct from the G-protein-responsive transmembranous adenylyl cyclases (tmAC). The structure of the catalytic unit of sAC is similar to tmAC, but sAC does not contain transmembranous domains, allowing localizations independent of the membranous compartment. sAC activity is stimulated by HCO3-, Ca2+ and is sensitive to physiologically relevant ATP fluctuations. sAC functions as a physiological sensor for carbon dioxide and bicarbonate, and therefore indirectly for pH. Here we review the physiological role of sAC in different human tissues with a major focus on the lung. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease, guest edited by J. Buck and L.R. Levin.

Original languageEnglish
Pages (from-to)2584-2592
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1842
Issue number12
DOIs
StatePublished - Dec 1 2014

Fingerprint

Adenylyl Cyclases
Health
Physiological Phenomena
Second Messenger Systems
Bicarbonates
GTP-Binding Proteins
Carbon Dioxide
Adenosine Triphosphate
Lung

Keywords

  • Airways
  • Bicarbonate
  • CAMP
  • Lung
  • SAC
  • Soluble adenylyl cyclase

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Soluble adenylyl cyclase in health and disease. / Schmid, Andreas; Meili, Dimirela; Salathe, Matthias A.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1842, No. 12, 01.12.2014, p. 2584-2592.

Research output: Contribution to journalArticle

Schmid, Andreas ; Meili, Dimirela ; Salathe, Matthias A. / Soluble adenylyl cyclase in health and disease. In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 2014 ; Vol. 1842, No. 12. pp. 2584-2592.
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