Soluble adenylyl cyclase in health and disease

Andreas Schmid, Dimirela Meili, Matthias Salathe

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The second messenger cAMP is integral for many physiological processes. Soluble adenylyl cyclase (sAC) was recently identified as a widely expressed intracellular source of cAMP in mammalian cells. sAC is evolutionary, structurally, and biochemically distinct from the G-protein-responsive transmembranous adenylyl cyclases (tmAC). The structure of the catalytic unit of sAC is similar to tmAC, but sAC does not contain transmembranous domains, allowing localizations independent of the membranous compartment. sAC activity is stimulated by HCO3-, Ca2+ and is sensitive to physiologically relevant ATP fluctuations. sAC functions as a physiological sensor for carbon dioxide and bicarbonate, and therefore indirectly for pH. Here we review the physiological role of sAC in different human tissues with a major focus on the lung. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease, guest edited by J. Buck and L.R. Levin.

Original languageEnglish (US)
Pages (from-to)2584-2592
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1842
Issue number12
DOIs
StatePublished - Dec 1 2014

Keywords

  • Airways
  • Bicarbonate
  • CAMP
  • Lung
  • SAC
  • Soluble adenylyl cyclase

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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