Solitary fibrous tumor of the nasal cavity and paranasal sinuses

L. R. Zukerberg, Andrew Rosenberg, G. Randolph, B. Z. Pilch, M. L. Goodman

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

We report two solitary fibrous tumors of the nasal cavity and paranasal sinuses that were histologically and immunohistochemically virtually identical to solitary fibrous tumors (fibrous mesotheliomas) of the pleura. One tumor arose in a 48-year-old woman and the other in a 45-year-old woman. Both patients presented with nasal symptoms, and both patients are alive without evidence of disease 6 months and 1 year after excision. The tumors had a disorganized or 'patternless' arrangement of spindle cells in a collagenous background and prominent vascular channels of varying size. Immunoperoxidase stains on paraffin sections showed staining of the cells for vimentin only; there was no staining for keratin, S-100 protein, desmin, and actin. Both cases presented some degree of diagnostic difficulty and had to be distinguished from other spindle cell tumors of the nasal cavity and paranasal sinuses, such as hemangiopericytoma, angiofibroma, and fibrous histiocytoma.

Original languageEnglish
Pages (from-to)126-130
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume15
Issue number2
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Solitary Fibrous Tumors
Paranasal Sinuses
Nasal Cavity
Pleural Solitary Fibrous Tumor
Angiofibroma
Benign Fibrous Histiocytoma
Staining and Labeling
Hemangiopericytoma
Neoplasms
Desmin
S100 Proteins
Pleura
Vimentin
Keratins
Nose
Paraffin
Blood Vessels
Actins
Coloring Agents

Keywords

  • Fibrous mesothelioma
  • Nasal cavity
  • Paranasal sinuses
  • Solitary fibrous tumor

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Zukerberg, L. R., Rosenberg, A., Randolph, G., Pilch, B. Z., & Goodman, M. L. (1991). Solitary fibrous tumor of the nasal cavity and paranasal sinuses. American Journal of Surgical Pathology, 15(2), 126-130.

Solitary fibrous tumor of the nasal cavity and paranasal sinuses. / Zukerberg, L. R.; Rosenberg, Andrew; Randolph, G.; Pilch, B. Z.; Goodman, M. L.

In: American Journal of Surgical Pathology, Vol. 15, No. 2, 01.01.1991, p. 126-130.

Research output: Contribution to journalArticle

Zukerberg, LR, Rosenberg, A, Randolph, G, Pilch, BZ & Goodman, ML 1991, 'Solitary fibrous tumor of the nasal cavity and paranasal sinuses', American Journal of Surgical Pathology, vol. 15, no. 2, pp. 126-130.
Zukerberg LR, Rosenberg A, Randolph G, Pilch BZ, Goodman ML. Solitary fibrous tumor of the nasal cavity and paranasal sinuses. American Journal of Surgical Pathology. 1991 Jan 1;15(2):126-130.
Zukerberg, L. R. ; Rosenberg, Andrew ; Randolph, G. ; Pilch, B. Z. ; Goodman, M. L. / Solitary fibrous tumor of the nasal cavity and paranasal sinuses. In: American Journal of Surgical Pathology. 1991 ; Vol. 15, No. 2. pp. 126-130.
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