Solid-state, pulsed-wave, mid-infrared coronary laser angioplasty in de novo versus restenosis lesions: Observations from a multicenter study

O. Topaz, M. McIvor, Eduardo De Marchena

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The following is a study of the response of de novo versus restenosis coronary lesions to pulsed-wave, mid-infrared (holmium:YAG) laser assisted angioplasty. De novo lesions contain thrombi, cholesterol, and fibrosis, whereas restenotic lesions are composed of smooth muscle cells corresponding to injury caused by preceding balloon inflations. It is not known whether the different composition affects results of treatment by laser. In a clinical multicenter study, a mid-infrared, solid-state, pulsed-wave laser (holmium:YAG, 2.1 μm wavelength, 250-600 mJ/pulse, 5 Hz) was applied for revascularization of de novo and restenosis coronary lesions. Analysis of data was undertaken to document laser success, complications, and restenosis rate and to define whether the type of lesion treated had an effect on laser success and related complications. A total of 1340 patients with 1465 stenoses presented with symptomatic coronary artery disease. Laser success was 87 and 86% in these lesions, respectively. Overall procedural success of 93% was achieved. Restenosis lesions, known to be composed of smooth muscle proliferation, needed more laser energy for ablation than de novo lesions, which contain an atherosclerotic plaque (130 ± 123 pulses vs 109 ± 31, p = 0.001). Procedure-related Q-wave myocardial infarction was significantly higher in patients with de novo lesions over patients with restenosis lesions (1.4 vs 0.2%, p = 0.05). With the mid-infrared, pulsed-wave, holmium:YAG laser, the composition of the target lesion affects the energy level required, as well as the procedure-related complications.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalJournal of Clinical Laser Medicine and Surgery
Volume13
Issue number5
StatePublished - Oct 1 1995
Externally publishedYes

Fingerprint

Laser Angioplasty
Infrared lasers
Multicenter Studies
Lasers
Coronary Restenosis
Holmium
Solid-State Lasers
Laser-Assisted Balloon Angioplasty
Infrared radiation
Economic Inflation
Muscle
Laser Therapy
Atherosclerotic Plaques
Smooth Muscle Myocytes
Smooth Muscle
Coronary Artery Disease
Pathologic Constriction
Thrombosis
Fibrosis
Myocardial Infarction

ASJC Scopus subject areas

  • Biomedical Engineering
  • Surgery

Cite this

@article{6a5c0be474bd4f7f9114f731ba7211ce,
title = "Solid-state, pulsed-wave, mid-infrared coronary laser angioplasty in de novo versus restenosis lesions: Observations from a multicenter study",
abstract = "The following is a study of the response of de novo versus restenosis coronary lesions to pulsed-wave, mid-infrared (holmium:YAG) laser assisted angioplasty. De novo lesions contain thrombi, cholesterol, and fibrosis, whereas restenotic lesions are composed of smooth muscle cells corresponding to injury caused by preceding balloon inflations. It is not known whether the different composition affects results of treatment by laser. In a clinical multicenter study, a mid-infrared, solid-state, pulsed-wave laser (holmium:YAG, 2.1 μm wavelength, 250-600 mJ/pulse, 5 Hz) was applied for revascularization of de novo and restenosis coronary lesions. Analysis of data was undertaken to document laser success, complications, and restenosis rate and to define whether the type of lesion treated had an effect on laser success and related complications. A total of 1340 patients with 1465 stenoses presented with symptomatic coronary artery disease. Laser success was 87 and 86{\%} in these lesions, respectively. Overall procedural success of 93{\%} was achieved. Restenosis lesions, known to be composed of smooth muscle proliferation, needed more laser energy for ablation than de novo lesions, which contain an atherosclerotic plaque (130 ± 123 pulses vs 109 ± 31, p = 0.001). Procedure-related Q-wave myocardial infarction was significantly higher in patients with de novo lesions over patients with restenosis lesions (1.4 vs 0.2{\%}, p = 0.05). With the mid-infrared, pulsed-wave, holmium:YAG laser, the composition of the target lesion affects the energy level required, as well as the procedure-related complications.",
author = "O. Topaz and M. McIvor and {De Marchena}, Eduardo",
year = "1995",
month = "10",
day = "1",
language = "English",
volume = "13",
pages = "319--323",
journal = "Photomedicine and Laser Surgery",
issn = "1549-5418",
publisher = "Mary Ann Liebert Inc.",
number = "5",

}

TY - JOUR

T1 - Solid-state, pulsed-wave, mid-infrared coronary laser angioplasty in de novo versus restenosis lesions

T2 - Observations from a multicenter study

AU - Topaz, O.

AU - McIvor, M.

AU - De Marchena, Eduardo

PY - 1995/10/1

Y1 - 1995/10/1

N2 - The following is a study of the response of de novo versus restenosis coronary lesions to pulsed-wave, mid-infrared (holmium:YAG) laser assisted angioplasty. De novo lesions contain thrombi, cholesterol, and fibrosis, whereas restenotic lesions are composed of smooth muscle cells corresponding to injury caused by preceding balloon inflations. It is not known whether the different composition affects results of treatment by laser. In a clinical multicenter study, a mid-infrared, solid-state, pulsed-wave laser (holmium:YAG, 2.1 μm wavelength, 250-600 mJ/pulse, 5 Hz) was applied for revascularization of de novo and restenosis coronary lesions. Analysis of data was undertaken to document laser success, complications, and restenosis rate and to define whether the type of lesion treated had an effect on laser success and related complications. A total of 1340 patients with 1465 stenoses presented with symptomatic coronary artery disease. Laser success was 87 and 86% in these lesions, respectively. Overall procedural success of 93% was achieved. Restenosis lesions, known to be composed of smooth muscle proliferation, needed more laser energy for ablation than de novo lesions, which contain an atherosclerotic plaque (130 ± 123 pulses vs 109 ± 31, p = 0.001). Procedure-related Q-wave myocardial infarction was significantly higher in patients with de novo lesions over patients with restenosis lesions (1.4 vs 0.2%, p = 0.05). With the mid-infrared, pulsed-wave, holmium:YAG laser, the composition of the target lesion affects the energy level required, as well as the procedure-related complications.

AB - The following is a study of the response of de novo versus restenosis coronary lesions to pulsed-wave, mid-infrared (holmium:YAG) laser assisted angioplasty. De novo lesions contain thrombi, cholesterol, and fibrosis, whereas restenotic lesions are composed of smooth muscle cells corresponding to injury caused by preceding balloon inflations. It is not known whether the different composition affects results of treatment by laser. In a clinical multicenter study, a mid-infrared, solid-state, pulsed-wave laser (holmium:YAG, 2.1 μm wavelength, 250-600 mJ/pulse, 5 Hz) was applied for revascularization of de novo and restenosis coronary lesions. Analysis of data was undertaken to document laser success, complications, and restenosis rate and to define whether the type of lesion treated had an effect on laser success and related complications. A total of 1340 patients with 1465 stenoses presented with symptomatic coronary artery disease. Laser success was 87 and 86% in these lesions, respectively. Overall procedural success of 93% was achieved. Restenosis lesions, known to be composed of smooth muscle proliferation, needed more laser energy for ablation than de novo lesions, which contain an atherosclerotic plaque (130 ± 123 pulses vs 109 ± 31, p = 0.001). Procedure-related Q-wave myocardial infarction was significantly higher in patients with de novo lesions over patients with restenosis lesions (1.4 vs 0.2%, p = 0.05). With the mid-infrared, pulsed-wave, holmium:YAG laser, the composition of the target lesion affects the energy level required, as well as the procedure-related complications.

UR - http://www.scopus.com/inward/record.url?scp=0029379660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029379660&partnerID=8YFLogxK

M3 - Article

C2 - 10163494

AN - SCOPUS:0029379660

VL - 13

SP - 319

EP - 323

JO - Photomedicine and Laser Surgery

JF - Photomedicine and Laser Surgery

SN - 1549-5418

IS - 5

ER -