Sodium orthovanadate treatment reverses protracted methionine administration induced schizophrenia like behavior in rats

Ashish Kumar Rehni, Nirmal Singh, Seema Jindal

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Suppression of Akt (Protein kinase B) has been implicated in schizophrenia, the effect of which has been documented to be reversed by tyrosine phosphatase inhibition. Present study has been designed to study the effect of sodium orthovanadate, a tyrosine phosphatase inhibitor, on protracted methionine administration induced schizophrenia-like behavior in rats. Schizophrenia-like behavior was assessed in number of circuits of cage (locomotor activity), number of climbs of sides (climbing), number of rears, face washing, scratching and chewing (stereotypy). Methionine administration (1.7g/kg/d, p.o.) for a period of 30 days elicited schizophrenia-like behavior in rats as assessed in terms of the measures of locomotor activity, climbing and stereotypy. However, sodium orthovanadate (15, 30 & 60 mg/kg, i.p.) coadministration from day 15 to day 30 markedly reduced this methionine induced increase in locomotor activity (from 40 ± 5.45 to 22 ± 2.82), climbing (from 57 ± 4.05 to 22 ± 2.12) as well as stereotypy (from 159 ± 6.9 to 59 ± 3.9). Sodium orthovanadate treatment induced reversal of protracted methionine administration induced schizophrenia like behavior in rats reflecting that inhibition of tyrosine phosphatase might be a useful approach in the therapeutics of schizophrenia.

Original languageEnglish (US)
Pages (from-to)67-70
Number of pages4
JournalIranian Journal of Pharmacology and Therapeutics
Volume6
Issue number1
StatePublished - Jan 2007
Externally publishedYes

Keywords

  • Methionine
  • Schizophrenia
  • Sodium orthovanadate
  • Tyrosine phosphatase

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'Sodium orthovanadate treatment reverses protracted methionine administration induced schizophrenia like behavior in rats'. Together they form a unique fingerprint.

Cite this