Abstract
Injection drug use is a major risk behavior associated with transmission of HIV-1B. Yet, despite its importance there have not been many detailed studies characterizing the transmission of HIV-1B in well-defined injection drug use networks. This preliminary study characterized people who were closely associated and injected drugs together under private circumstances compared to those who injected drugs in a context of public risk locales with many injectors in attendance. In this study, we examined networks of HIV-1B seropositive injection drug users (IDUs). We wished to ascertain whether socioepidemiological connections and relationships (including IDU and sexual) among individuals who inject drugs would be reflected in the molecular relatedness and clustering of their HIV-1B nucleotide and protein sequences-specifically hypervariable domains (V1-V5) of the HIV-1B envelope (env) gene. We wished to learn if there was a link between subject socioepidemiology and viral sequence diversity, phylogenetic relationships, signatures, thermodynamics, and glycosylation patterns. This chapter addresses whether in risk locales where many people inject together, there are variations in probability of relatedness of HIV-1B env sequences. In addition, it is pointed out that IDU behaviors are associated with psychiatric morbidities.
| Original language | English (US) |
|---|---|
| Title of host publication | Global Virology II - HIV and NeuroAIDS |
| Publisher | Springer New York |
| Pages | 347-373 |
| Number of pages | 27 |
| ISBN (Electronic) | 9781493972906 |
| ISBN (Print) | 9781493972883 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- Cluster
- Entropy
- ENV V1-V5 hypervariable domains
- Envelope
- Glycosylation
- HIV-1B infection
- Injection drug user (IDU)
- Molecular similarity
- Network
- Nucleotide sequence
- Phylogenetic analysis (phylogeny)
- Protein sequence
- Psychiatric morbidities
- Relationship
- Risk behavior
- Risk locale
- Sexual risk
- Socioepidemiology
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
- Neuroscience(all)
Cite this
Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity : A preliminary study. / Shapshak, Paul; Foley, Brian T.; Balaji, Seetharaman; Segal, David M.; McCoy, Clyde B; Page, John.
Global Virology II - HIV and NeuroAIDS. Springer New York, 2017. p. 347-373.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity
T2 - A preliminary study
AU - Shapshak, Paul
AU - Foley, Brian T.
AU - Balaji, Seetharaman
AU - Segal, David M.
AU - McCoy, Clyde B
AU - Page, John
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Injection drug use is a major risk behavior associated with transmission of HIV-1B. Yet, despite its importance there have not been many detailed studies characterizing the transmission of HIV-1B in well-defined injection drug use networks. This preliminary study characterized people who were closely associated and injected drugs together under private circumstances compared to those who injected drugs in a context of public risk locales with many injectors in attendance. In this study, we examined networks of HIV-1B seropositive injection drug users (IDUs). We wished to ascertain whether socioepidemiological connections and relationships (including IDU and sexual) among individuals who inject drugs would be reflected in the molecular relatedness and clustering of their HIV-1B nucleotide and protein sequences-specifically hypervariable domains (V1-V5) of the HIV-1B envelope (env) gene. We wished to learn if there was a link between subject socioepidemiology and viral sequence diversity, phylogenetic relationships, signatures, thermodynamics, and glycosylation patterns. This chapter addresses whether in risk locales where many people inject together, there are variations in probability of relatedness of HIV-1B env sequences. In addition, it is pointed out that IDU behaviors are associated with psychiatric morbidities.
AB - Injection drug use is a major risk behavior associated with transmission of HIV-1B. Yet, despite its importance there have not been many detailed studies characterizing the transmission of HIV-1B in well-defined injection drug use networks. This preliminary study characterized people who were closely associated and injected drugs together under private circumstances compared to those who injected drugs in a context of public risk locales with many injectors in attendance. In this study, we examined networks of HIV-1B seropositive injection drug users (IDUs). We wished to ascertain whether socioepidemiological connections and relationships (including IDU and sexual) among individuals who inject drugs would be reflected in the molecular relatedness and clustering of their HIV-1B nucleotide and protein sequences-specifically hypervariable domains (V1-V5) of the HIV-1B envelope (env) gene. We wished to learn if there was a link between subject socioepidemiology and viral sequence diversity, phylogenetic relationships, signatures, thermodynamics, and glycosylation patterns. This chapter addresses whether in risk locales where many people inject together, there are variations in probability of relatedness of HIV-1B env sequences. In addition, it is pointed out that IDU behaviors are associated with psychiatric morbidities.
KW - Cluster
KW - Entropy
KW - ENV V1-V5 hypervariable domains
KW - Envelope
KW - Glycosylation
KW - HIV-1B infection
KW - Injection drug user (IDU)
KW - Molecular similarity
KW - Network
KW - Nucleotide sequence
KW - Phylogenetic analysis (phylogeny)
KW - Protein sequence
KW - Psychiatric morbidities
KW - Relationship
KW - Risk behavior
KW - Risk locale
KW - Sexual risk
KW - Socioepidemiology
UR - http://www.scopus.com/inward/record.url?scp=85042625673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042625673&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-7290-6_15
DO - 10.1007/978-1-4939-7290-6_15
M3 - Chapter
SN - 9781493972883
SP - 347
EP - 373
BT - Global Virology II - HIV and NeuroAIDS
PB - Springer New York
ER -