Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events

Marcela V. Maus, Sara Alexander, Michael R. Bishop, Jennifer N. Brudno, Colleen Callahan, Marco L. Davila, Claudia Diamonte, Jorg Dietrich, Julie C. Fitzgerald, Matthew J. Frigault, Terry J. Fry, Jennifer L. Holter-Chakrabarty, Krishna V. Komanduri, Daniel W. Lee, Frederick L. Locke, Shannon L. Maude, Philip L. McCarthy, Elena Mead, Sattva S. Neelapu, Tomas G. NeilanBianca D. Santomasso, Elizabeth J. Shpall, David T. Teachey, Cameron J. Turtle, Tom Whitehead, Stephan A. Grupp

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Immune effector cell (IEC) therapies offer durable and sustained remissions in significant numbers of patients with hematological cancers. While these unique immunotherapies have improved outcomes for pediatric and adult patients in a number of disease states, as 'living drugs,' their toxicity profiles, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), differ markedly from conventional cancer therapeutics. At the time of article preparation, the US Food and Drug Administration (FDA) has approved tisagenlecleucel, axicabtagene ciloleucel, and brexucabtagene autoleucel, all of which are IEC therapies based on genetically modified T cells engineered to express chimeric antigen receptors (CARs), and additional products are expected to reach marketing authorization soon and to enter clinical development in due course. As IEC therapies, especially CAR T cell therapies, enter more widespread clinical use, there is a need for clear, cohesive recommendations on toxicity management, motivating the Society for Immunotherapy of Cancer (SITC) to convene an expert panel to develop a clinical practice guideline. The panel discussed the recognition and management of common toxicities in the context of IEC treatment, including baseline laboratory parameters for monitoring, timing to onset, and pharmacological interventions, ultimately forming evidence- and consensus-based recommendations to assist medical professionals in decision-making and to improve outcomes for patients.

Original languageEnglish (US)
Article numbere001511
JournalJournal for ImmunoTherapy of Cancer
Volume8
Issue number2
DOIs
StatePublished - Dec 16 2020
Externally publishedYes

Keywords

  • adoptive
  • cell engineering
  • chimeric antigen
  • guidelines as topic
  • hematological neoplasms
  • immunotherapy
  • receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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