Social well-being is associated with less pro-inflammatory and pro-metastatic leukocyte gene expression in women after surgery for breast cancer

Devika R. Jutagir, Bonnie B. Blomberg, Charles S. Carver, Suzanne C. Lechner, Kiara R. Timpano, Laura C. Bouchard, Lisa M. Gudenkauf, Jamie M. Jacobs, Alain Diaz, Susan K. Lutgendorf, Steve W. Cole, Aaron S. Heller, Michael H. Antoni

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Purpose: Satisfaction with social resources, or “social well-being,” relates to better adaptation and longer survival after breast cancer diagnosis. Biobehavioral mechanisms linking social well-being (SWB) to mental and physical health may involve inflammatory signaling. We tested whether reports of greater SWB were associated with lower levels of pro-inflammatory and pro-metastatic leukocyte gene expression after surgery for non-metastatic breast cancer. Methods: Women (N = 50) diagnosed with non-metastatic (0–III) breast cancer were enrolled 2–8 weeks after surgery. SWB was assessed with the social/family well-being subscale of the FACT-B. Leukocyte gene expression for specific pro-inflammatory (cytokines, chemokines, and COX-2) and pro-metastatic genes (e.g., MMP9) was derived from microarray analysis. Results: Multiple regression analyses controlling for age, stage of disease, days since surgery, education, and body mass index (BMI) found higher levels of SWB related to less leukocyte pro-inflammatory and pro-metastatic gene expression (p < 0.05). Emotional well-being, physical well-being, and functional well-being did not relate to leukocyte gene expression (p > 0.05). Greater SWB remained significantly associated with less leukocyte pro-inflammatory and pro-metastatic gene expression after controlling for depressive symptoms. Conclusions: Results have implications for understanding mechanisms linking social resources to health-relevant biological processes in breast cancer patients undergoing primary treatment. Clinical Trial Registration Number: NCT01422551.

Original languageEnglish (US)
Pages (from-to)169-180
Number of pages12
JournalBreast cancer research and treatment
Volume165
Issue number1
DOIs
StatePublished - Aug 1 2017

Keywords

  • Breast cancer
  • Inflammation
  • Leukocyte gene expression
  • Social support
  • Social well-being

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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